Osteo Arthritis Knee
Conditions
Keywords
Knee osteoarthritis, power production, functional capacity
Brief summary
Knee osteoarthritis is an important cause of functional disabilities at old age. Previous research has demonstrated that individuals with knee osteoarthritis have reduced knee-extensor strength in comparison to healthy individuals. However, rapid power production declines more than strength as a consequence of ageing and is more predictive of functional capacity. However, limited research has investigated whether individuals with knee osteoarthritis have reduced ability to develop strength and power rapidly on top of reduced maximal strength capacities, which is the primary aim of the current study.
Interventions
DIAGNOSTIC_TESTMuscle function test
Power and strength tests of the knee-extensor muscles, handgrip strength, functional capacity tests
Sponsors
KU Leuven
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
50 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
Group with knee osteoarthritis: \- Diagnosed with knee osteoarthritis based on RX.
Exclusion criteria
Healthy group: * Systematic engagement in (resistance) exercise in the 12-months prior to participation * Cardiovascular disease * Neurological disorders * Cognitive malfunctioning * Severe knee or hip problems Group with knee osteoarthritis: * Systematic engagement in (resistance) exercise in the 12-months prior to participation * Cardiovascular disease * Neurological disorders * Cognitive malfunctioning * Severe hip problems
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of power development | up to 3 months | Subjects perform a test protocol on a Biodex dynamometer, consisting of isotonic contractions of the leg-extensor muscles. Subjects are instructed to kick as fast as possible against different (relative) loads. The rate of power development (watt/s) is defined as the linear slope of the power-time curve and is measured from the onset of movement till peak power. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Maximal isokinetic strength | up to 3 months | Maximal strength (Nm) is measured by means of unilateral isokinetic knee-extensor tests on a Biodex dynamometer. |
| Stair Climbing performance | up to 3 months | Stair ascent duration (in s), the time needed to ascent a flight of stairs. |
| Gait speed | up to 3 months | The average speed to walk 10m as fast as possible (in m/s). |
| Maximal isometric strength | up to 3 months | Maximal strength (Nm) is measured by means of unilateral isometric knee-extensor tests on a Biodex dynamometer. |
| Timed-up-and-go | up to 3 months | The time needed to stand up from a chair, walk 3m, turn, walk back and sit down. |
| Handgrip strength | up to 3 months | Handgrip strength (kg) evaluated with Jamar dynamometer. |
| 5 repetition sit-to-stand test | up to 3 months | The time needed to perform 5 sit-to-stand transitions (in s). |
Countries
Belgium
Outcome results
None listed