The Effect of Preoperative and Post Operative Misoprostol Administration on Intraoperative Blood Loss and Postpartum Hemorrhage in CS

Conditions

Post Partum Hemorrhage

Brief summary

• Patients will be divided into two groups 100 patients will receive routine ecbolics (for example oxytocin) after delivery of baby The 100 patients will receive routine ecbolics (for example oxytocin) after delivery of baby plus 400 microgram misoprostol rectally with catheterization and another 400 microgram rectally after closure of abdomen Then we will compare between two groups regarding * Intaoperative blood loss * Risk of Postpartum hemorraghe in the first 24 hrs * HB pre and postoperative for all patients Intraoperative blood loss will be estimated by the number and weight of soaked towels and amount of blood in suction unit

Detailed description

• Patients will be divided into two groups 100 patients will receive routine ecbolics (for example oxytocin) after delivery of baby The 100 patients will receive routine ecbolics (for example oxytocin) after delivery of baby plus 400 microgram misoprostol rectally with catheterization and another 400 microgram rectally after closure of abdomen Then we will compare between two groups regarding * Intaoperative blood loss * Risk of Postpartum hemorraghe in the first 24 hrs * HB pre and postoperative for all patients Intraoperative blood loss will be estimated by the number and weight of soaked towels and amount of blood in suction unit

Maged AM, Fawzi T, Shalaby MA, Samy A, Rabee MA, Ali AS, Hussein EA, Hammad B, Deeb WS.

2019-07-254 citations

10.1002/ijgo.12922

Interventions

PROCEDUREcesarean section

CS will be done by pfannenstiel incision , transverse lower uterine segment incision ,immediate cord clamping after delivery of baby , closure of uterus by 2 layers , closure of abdomen in layers

DRUGMisoprostol

The 100 patients will receive routine ecbolics (for example oxytocin) after delivery of baby plus 400 microgram misoprostol rectally with catheterization and another 400 microgram rectally after closure of abdomen

DRUGOxytocin

10 IU of oxytocin with fetal delivery

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 35 Years

Healthy volunteers

No

Inclusion criteria

women attending for elective CS. * Age between 20-35 years. * Normal placental site * Normal coagulation profile * Full term pregnancies(above 37 wks) * Medically free * Spinal anesthesia * Living baby * Average liquor by U/S

Exclusion criteria

* • Women attending for emergency CS * .age below 20 or above 35 * Abnormal placentation (Placenta previa,accrete,increta or percreta) * Women with coagulopathy * Preterm pregnancies (before 37 wks) * Medical disorder (Hypertension,Diabetes, Endocrinal disorder) * General anathesia * IUFD * Oligo or polyhydraminos by U/S

Design outcomes

Primary

Measure	Time frame
postpartum hemorrhage	24 hours after cesarean section

Countries

Egypt

Outcome results

None listed