Regional Anesthesia
Conditions
Brief summary
Infraclavicular brachial plexus block has been used more frequently with the development of high-resolution ultrasound. Compared with peripheral nerve block using landmark technique or nerve stimulator technique, ultrasound-guided peripheral nerve block decreases the required dose of local anesthetics. As the dose of the drug used decreases, the systemic toxic effects of local anesthetics are reduced. However, the decreased dose of the drugs might have influence on the onset time of local anesthetics. Thus, the investigator aimed to evaluated the onset time of the two equipotent local anesthetics, 0.375% ropivacaine and 0.25% levobupivacaine.
Interventions
ultrasound-guided infraclavicular brachial plexus block with 0.375% ropivacaine solution
ultrasound-guided infraclavicular brachial plexus block with 0.25% levobupivacaine solution
Sponsors
Asan Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
19 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* American Society of Anesthesiologists physical status 1-3 * Patients undergoing upper extremity surgery with infraclavicular brachial plexus block
Exclusion criteria
* Patients who do not agree to participate in clinical trial * Patients presenting with neurological deficits of the upper arm, severe coagulopathy, chronic renal failure, cardiopulmonary compromise, cerebral vascular disease, hypersensitivity to hyaluronidase or local anesthetics or local infection at the site of the infraclavicular block, pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| onset time of sensory block | up to 40 minutes | sensory block of 4 nerves(radial, median, ulnar, musculocutaneous nerve) was assessed with pin-prick test every 5 minutes till 40 minutes from the completion of drug injection |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| onset time of motor block | up to 40 minutes | motor block of 4 nerves(radial, median, ulnar, musculocutaneous nerve) was assessed with movement of fingers and elbow every 5 minutes till 40 minutes from the completion of drug injection |
| duration of analgesia | 24 hours | defined as time for first request by the patient |
Countries
South Korea
Outcome results
None listed