Cardiovascular Diseases, Cognition Disorders in Old Age, Dementia
Conditions
Brief summary
Cognition and locomotion are two human abilities controlled by the brain. Their decline is highly prevalent with aging, and is greater than the simple sum of their respective prevalence, suggesting a complex age-related interplay between cognition and locomotion. Recently, a systematic review and meta-analysis has provided evidence that poor gait performance predicts dementia and, in particular, has demonstrated that motoric cognitive risk (MCR) syndrome, which has been described in cognitively healthy individuals and combines subjective cognitive complaint with objective slow gait speed, is a pre-dementia syndrome. The uniqueness of motoric cognitive risk (MCR)syndrome is that it does not rely on a complex evaluation or laboratory investigations. Thus, it is easy to apply in population-based settings. The overall objective of the proposal is to examine the epidemiology of the newly reported motoric cognitive risk (MCR) syndrome, in the Quebec population using the database of the NuAge study.
Interventions
Participants' baseline characteristics will be summarized using means and standard deviations or frequencies and percentages, as appropriate.
Sponsors
Jewish General Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
45 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Individuals eligible for this study will be participants of the NuAge study
Exclusion criteria
* Individuals not eligible for the NuAge study * dementia * mobility disability * no information about cognitive complaint * no measure of walking speed
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cardio-vascular risk factors and diseases assessed using reported health condition | 1 day | medical history |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cardio-vascular risk factors and diseases assessed using physical examination: HW ratio | 1 day | hip-waist ratio |
| Cardio-vascular risk factors and diseases assessed using physical examination: blood pressure | 1 day | (value of systolic, diastolic when participants are seated in an upright position in a chair) |
| Disability and functional limitations | 1 day | Disability and functional limitations : ADL (activities of daily life) |
| Cardio-vascular risk factors and diseases assessed using physical examination: BMI | 1 day | body mass index |
| Cognitive performance | 1 day | Prospective Memory Test (PMT) |
| physical and mental health | 1 day | Number of drugs daily taken |
| Physical performance | 1 day | Muscle strength estimated using the handgrip strength |
| Depression | 1 day | measured by the 10 items of the Center for Epidemiological Studies Short Depression Scale. Participants with a score of 10 or greater are considered as depressed. Scores with more than 2 missing items will be excluded. |
Countries
Canada
Outcome results
None listed