Infertility
Conditions
Brief summary
Vienna Consensus has identified 10% damage rate after ICSI as a competency value. Despite the highest quality embryologists doing ICSI, degeneration sometimes occurs due to oocyte factors such as the fragile membrane, etc. Latrunculin A serves to facilitate spindle or pronuclear transfer procedures helping to reduce the damage rate with no harm reported. Using Latrunculin A during ICSI could serve to rescue some oocytes from the degeneration allowing for more chances of viable zygotes,
Interventions
OTHERMedium Supplemented with Latrunculin A
A medium with in-house supplementation of Latrunculin A to decrease oocyte degeneration after ICSI and improve the survival rate
Sponsors
Ibn Sina Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 42 Years
Healthy volunteers
No
Inclusion criteria
* ICSI participants
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| oocyte survival rate | 6 days of culture |
Secondary
| Measure | Time frame |
|---|---|
| Blastocyst formation rate | 6 days of culture |
| Blastocyst quality rate | 6 days of culture |
| fertilization rate | 6 days of culture |
| Implantation rate | 7 weeks |
| Ongoing pregnancy rate | 12 weeks |
| Clinical pregnancy rate | three months |
Countries
Egypt
Outcome results
None listed