Infertility
Conditions
Brief summary
Vienna Consensus has identified 10% damage rate after ICSI as a competency value. Despite the highest quality embryologists doing ICSI, degeneration sometimes occurs due to oocyte factors such as the fragile membrane, etc. Chaetoglobosin A serves to facilitate spindle or pronuclear transfer procedures helping to reduce the damage rate with no harm reported. Using Chaetoglobosin A during ICSI could serve to rescue some oocytes from the degeneration allowing for more chances of viable zygotes.
Interventions
OTHERMedium Supplemented with Chaetoglobosin A
A medium with in-house supplementation of Chaetoglobosin A to decrease oocyte degeneration after ICSI and improve the survival rate
Sponsors
Banoon IVF Center
Qena Fertility Center
Ibn Sina Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 42 Years
Healthy volunteers
No
Inclusion criteria
* All ICSI participants agreed
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oocyte Survival after ICSI | two days | Survived oocytes per MII injected |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rate of top-quality embryo | 6 days of culture | Rate of top-quality embryo per fertilized oocytes |
| blastocyst formation and quality | 6 days of culture | Number of formed blastocyst and high-quality blastocyst per fertilized oocytes |
| blastocyst utilization rate | 6 days of culture | Number of transferred and vitrified embryos per fertilized oocytes |
| Fertilization rate | 6 days of culture | — |
| Implantation rate | 7 weeks | sacs with a heartbeat per embryo transferred |
| Ongoing pregnancy rate | 12 weeks | — |
| clinical pregnancy rate | 7 weeks | Number of pregnant women per recruited cycles |
Countries
Egypt
Outcome results
None listed