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Evaluation of Post-extraction Socket Preservation With Camelline Versus Bovine Deproteinized Xenograft

Evaluation of Post-extraction Socket Preservation With Camelline Versus Bovine Deproteinized Xenograft (Pilot Trial)

Status
UNKNOWN
Phases
Early Phase 1
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03677479
Enrollment
10
Registered
2018-09-19
Start date
2019-03-31
Completion date
2020-08-31
Last updated
2019-01-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Socket Preservation

Keywords

bone grafts, xenograft

Brief summary

Alveolar ridge preservation following tooth extraction has the ability to maintain the ridge dimensions and allow the implant placement in an ideal position fulfilling both functional and aesthetic results. Postextraction socket healing commonly results in resorption of the alveolar ridge. To prevent this clinical situation, different authors have described several surgical procedures, ranging from regenerative techniques for socket preservation to immediate implant placement. Regenerative techniques have been widely tested in controlled and uncontrolled studies with various materials and clinical approaches: bone grafting alone, including autografts, allografts, xenografts, and alloplasts; membrane alone, whether absorbable or not; and membrane in conjunction with grafting.

Detailed description

Various classic studies in the 1960s showed that the resorption process of the postextraction alveolus in both jaws was significantly more pronounced on the buccal aspect. This comes as no surprise, as the buccal surface of the anterior alveolar ridge is commonly thin and fragile. The maxilla tends to exhibit greater reductions in width than in height. The loss of tissue contour takes place mostly during the first 1 to 3 months following tooth extraction. Because the healing patterns of human sockets are unpredictable architecture), then such common procedures as extractions may lead to intraoral situations in which the remaining healed ridge does not allow for an esthetic and functional solution without the aid of significant bone grafting.

Interventions

PROCEDUREsocket preservation procedure

socket preservation of post extraction site using bone xenografts

Sponsors

Cairo University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Outcomes Assessor)

Masking description

single blinded

Intervention model description

pilot randomized clinical trial

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Teeth with: root fractures, endodontic treatment failures, advanced caries lesions or any other cause that make tooth non-restorable and indicated for extraction. * Healthy non-smoker patients

Exclusion criteria

* Medically compromised patients. * Pregnant females. * History of malignancy or radiotherapy/chemotherapy for malignancy in the past 5 years. * History of active bone metabolic disease.

Design outcomes

Primary

MeasureTime frameDescription
patient-reported outcomewithin first week postoperativelyassessment of post-operative complication( pain, swelling, bleeding, infection)

Secondary

MeasureTime frameDescription
ridge contour changes3 month, 6 monthdimentional changes after extraction and socket preservation

Contacts

Primary ContactGhada Adayil, Msc
ghada.adayil@dentistry.cu.edu.eg(+202)01006010412

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026