Glaucoma, Primary Open Angle
Conditions
Keywords
Primary Open Angle Glaucoma (POAG), Optical Coherence Tomography Angiography (OCTA), Caffeine, Macular Blood Flow, Peripapillary Blood Flow
Brief summary
Caffeine is the most widely consumed drinking nutrient in the world. Caffeine effects various organs and the vascular system. It decreases ocular blood flow due to vasoconstriction.
Detailed description
Ingestion of caffeine in glaucoma patients and healthy subjects may decrease peripapillary and macular blood flow in the back of the eye. The primary objective of this study is to assess the acute changes in peripapillary and macular blood flow before and after an intake of oral caffeine (200 milligram tablet) in glaucoma patients and healthy subjects by using optical coherence tomography angiography (OCTA) scans. This novel imaging tool creates three-dimensional angiograms to assesses signal changes caused by flowing blood cells in a non-invasive angiogram scan. Blood flow is shown as vessel density measured in percentage.
Interventions
DIETARY_SUPPLEMENTCaffeine tablet
Each eligible participant will receive one 200 mg caffeine tablet to ingest after completing all baseline study tasks.
Sponsors
Wills Eye
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
All eyes will undergo imaging to measure blood flow in the back of the eye (retina and optic nerve) using the Avanti AngioVue HD OCTA (optical coherence tomography angiography)
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* age 18 to 90 years * diagnosis of primary open angle glaucoma (Mild, Moderate and Advanced) * healthy subjects with no eye disease
Exclusion criteria
* Diseases, ophthalmic or systemic, that are likely to affect OCTA results * greater than moderate cataract * nystagmus * inability to look at target * macular degeneration other than mild drusen or pigmentary changes * diabetic retinopathy * neovascular glaucoma or non-glaucoma optic neuropathies * current macular edema, prior laser to retina, inflammatory retinopathy or choroidopathy * keratoconus, corneal ectasia, central corneal scarring * rheumatologic diseases or Raynaud's phenomena * pregnant and lactating women * mental illness or alcohol addiction * pre-existing bladder symptoms, cardiac disease or sleep disorder * refractive spherical diopter greater than 5 or cylinder greater than 3 * possible tolerance to caffeine (drinking more than 1 cup coffee per day).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood flow change in back of eye before and after caffeine | Baseline, Hour 1, Hour 2 | Optical Coherence Tomography Angiography (OCTA) will be obtained using the Avanti AngioVue High Definition (HD) OCTA by Optovue. Images will include standard 4.5mm HD disc scan, 6mm HD retina scan, regular optic nerve head (ONH) structural scan, 3D-disc baseline scan and a regular ganglion cell complex analysis (GCCA) structural scan. This will measure blood flow changes in the back of the eye by imaging vessel density in percentage before then 1 and 2 hours after caffeine. |
Countries
United States
Contacts
Primary ContactM. Reza Razeghinejad, MD
Backup ContactJeanne Molineaux, COA
Outcome results
None listed