Medulloblastoma
Conditions
Keywords
TOMO irradiation
Brief summary
The aim of the study was to improve local control and long-term survival in children with medulloblastoma, reduce the side effects of treatment and improve quality of life.
Detailed description
The technical advantages of Tomotherapy HD in the radiotherapy of children medulloblastoma (advantages in clinical operation and physics) were transformed into clinical advantages, and the possible mechanisms were explored.
Interventions
DEVICETomotherapy HD
Patients with Medulloblastoma receiving Tomotherapy
DEVICE3DCRT
Patients with Medulloblastoma receiving Three-Dimensional Conformal Radiation Therapy
Sponsors
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
3 Years to 12 Years
Healthy volunteers
No
Inclusion criteria
* The patient was diagnosed as myeloblastoma by surgical pathology with definite pathological classification. MRI of the head and spinal cord before and after operation, with definite staging; Radiotherapy was performed within 28 days after surgery.
Exclusion criteria
* Previous radiotherapy in the whole brain, whole spinal cord or primary focus; Postoperative radiotherapy for more than 28 days.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| QoL(quality of life) | 2 years | Changes in quality of life were assessed by EORTC QLQ-C30 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| PFS (progression free survival) | 2 years | from the first day of therapy to the date of disease progression or death from any cause, whichever was first (according the criterion of RECIST 1.1 ). |
| OS (overall survival) | 2 years | from the first day of therapy to death or last follow-up |
Countries
China
Contacts
Primary Contactchuanying zhu, MD
Outcome results
None listed