Neurotrophic Factors, Tight Junction Proteins, and Cytokines in IBS

Expression of Neurotrophic Factors, Tight Junction Proteins, and Cytokines According to the Irritable Bowel Syndrome Subtype and Sex

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03675100

Enrollment

100

Registered

2018-09-18

Start date

2009-06-30

Completion date

2019-12-31

Last updated

2020-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irritable Bowel Syndrome, Pathophysiology, Tight Junction Alteration

Keywords

Irritable bowel syndrome, Subtype, Tight junction, Sex

Brief summary

To evaluate the role of neurotrophic factors (NGF, GDNF, TRPV-1), to quantity tight junction proteins (ZO-1, occludin, claudin) and cytokines (IL-8, TNF-a, IL-1b) in the colonic mucosa of IBS patients and also clarify sex differences in the pathophysiology of IBS.

Interventions

PROCEDUREcolonoscopic mucosal biopsy

colonoscopic mucosal biopsy was undertaken for every participant

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Control group Those who were between 18 and 80 years old and did not have any abnormalities in colonoscopy * Irritable bowel syndrome group Patients who diagnosed as irritable bowel syndrome according to the ROME III criteria

Exclusion criteria

* history of IBD * abdominal operation * severe systemic disease * malignancy,

Design outcomes

Primary

Measure	Time frame	Description
NGF, GDNF, and TRPV-1 mRNA expression of colonic mucosa	up to 24 weeks	real-time qPCR

Secondary

Measure	Time frame	Description
ZO-1, Occludin, and Claudin mRNA expression of colonic mucosa	up to 24 weeks	real-time qPCR and Western blot
IL-8, TNF-a, and IL-1b mRNA expression of colonic mucosa	up to 24 weeks	real-time qPCR

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026