Coagulopathy
Conditions
Keywords
hydroxyethyl starch, gelatin, ROTEM, coagulation
Brief summary
Modern crystalloid and colloid solutions are balanced solutions which are increasingly used in perioperative period. However, studies investigating their negative effect on whole blood coagulation are missing. The aim of our study was to assess the effect of modern balanced crystalloid and colloid solutions on whole blood coagulation in vivo using rotational thromboelastometry.
Detailed description
Blood samples were obtained from 30 patients during knee arthroscopy before and after administration of 500 ml of modern balanced crystalloid, hydroxyethyl starch (HES) or gelatin. Rotational thromboelastometry (EXTEM, INTEM and FIBTEM tests) were performed to assess negative effect of fluid solutions on whole blood coagulation.
Interventions
OTHERhydroxyethyl starch
After induction to anaesthesia patients received either hydroxyethyl starch or gelatin or crystalloids
Sponsors
University Hospital, Motol
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy patients undergoing knee arthroscopy
Exclusion criteria
* receiving antiplatelet drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| thromboelastometry assessment of coagulation | 3 months | ROTEM tests- clotting time in seconds, Maximal clot firmness in mm, alpha angle of in degree of following tests EXTEM, INTEM, FIBTEM |
Countries
Czechia
Outcome results
None listed