Magnetic Resonance Imaging Sequences
Conditions
Keywords
Healthy volunteers, Test, Optimization
Brief summary
Magnetic Resonance Imaging (MRI) performance depends on equipment performance, equipment maintenance and relevance of MRI sequence used. To optimize MRI performance, it's necessary to develop, optimize, test and validate new acquisition sequences for enhanced diagnosis and therapy monitoring. These new sequences will allow better spatial resolution and specificity while reducing acquisition time.
Detailed description
The purpose of the present study is to test and optimize, on healthy subjects, specific MRI acquisition sequences firstly developed in a preclinical phase on phantoms (inert objects containing solutions or gels) and animal (Pig, sheep). This study will allow the investigators to define practical acquisition parameters that will allow reproducible results and precise definition of clinically relevant examination protocols for each new developed sequence.
Interventions
DEVICEMRI acquisitions
Procedure of the study is an MRI exam without any injection or invasive procedure, that will be performed on the Siemens Magnetom Aera imager of Liryc institute (L'Institut de RYthmologie et modélisation Cardiaque) (Xavier Arnozan site - Bordeaux)
Sponsors
University Hospital, Bordeaux
L'Institut de RYthmologie et modélisation Cardiaque (IHU LIRYC)
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers (over 18 yo), * Male or female, * Affiliated to social security, * Without any contraindication to MRI exam and who will have signed a written inform consent.
Exclusion criteria
* Individuals deprived of liberty, * Under guardianship or curatorship, * Persons with known disease which could disturb MRI acquisition or with absolute or relative contraindication to an MRI examination * Pregnant women, * Breastfeeding women, * Women without effective contraception, * Participants who refused to be informed of the possible discovery of a significant anomaly, * Persons involved in an interventional study with a drug or an implantable device.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Image quality | Day 0 | — |
| Signal to noise ratio | Day 0 | — |
| Contrasts between structurally different regions | Day 0 | The values of the signal intensities will be measured in adjacent structures of interest. The difference between these values divided by the noise will be calculated to quantify the contrast-to-noise ratio between these structures. The higher this value is, the better is the sequence in its ability to differentiate these structures from one another. |
| Total acquisition time | Day 0 | — |
| Qualitative interpretation of image quality to respiratory and cardiac motions | Day 0 | In the presence of improper compensation for cardiac and / or respiratory movements, the images may appear blurred. The qualitative interpretation of image quality will be performed by visual image analysis. |
| Quantitative interpretation of image quality to respiratory and cardiac motions | Day 0 | In the presence of improper compensation for cardiac and / or respiratory movements, the images may appear blurred. The quantitative interpretation of image quality will be performed by a measurement of sharpness of contours between adjacent structures of interest. |
Countries
France
Contacts
CONTACTHubert COCHET, MD
CONTACTLorena SANCHEZ BLANCO, MD
PRINCIPAL_INVESTIGATORHubert COCHET, MD
University Hospital, Bordeaux
Outcome results
None listed