Pain, Postoperative, Trismus, Swelling
Conditions
Keywords
Leukocyte- and platelet rich fibrin, Advanced platelet rich fibrin, Impacted mandibular third molar surgery
Brief summary
In this study, it was aimed to investigating and comparing the postoperative effects of leukocyte- and platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF) in terms of pain, swelling on the cheek, and trismus after mandibular third molar surgery. The study included a total of 27 patients with bilateral impacted mandibular third molar which surgically operated at different times. Patients were evaluated in two randomly separated groups. For the first group; A-PRF and for the second group; L-PRF was applied into the tooth socket. The outcomes variables were; pain, swelling, the number of analgesics taken, and trismus. These variables were also assessed on the basis of; 1st, 2nd, 3rd and 7th days following the operation.
Interventions
blood samples collected in 10 ml of vacuumed plain glass tubes were centrifuged for 14 minutes at 1500 rpm without anticoagulant agents in order to obtain A-PRF
GENETICLeukocyte- and platelet-rich fibrin (L-PRF)
blood samples collected in 10 ml of glass coated plastic tubes were centrifuged without anticoagulant agents for 10 minutes in order to obtain L-PRF
Sponsors
Near East University, Turkey
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Outcomes Assessor)
Intervention model description
patients with bilateral impacted mandibular third molar which surgically operated at different times
Eligibility
Sex/Gender
ALL
Age
18 Years to 26 Years
Healthy volunteers
Yes
Inclusion criteria
* age≥18 * the presence of bilaterally symmetrically impacted mandibular third molar, which requires an extraction for prophylactic reasons * absence of systemic diseases * absence of chronic opioid taken; * not being pregnant * not smoking and no alcohol usage * the absence of allergy to penicillin or any other drugs used during standardized postoperative therapy.
Exclusion criteria
* tooth needed to be sectioning during the operation * operation time exceeding 30 minutes * the cases with severe periodontal disease or acute pericoronitis, * the cases using antibiotics for an existing infection * the cases not capable of following postoperative instructions
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain Scores Evaluted | 1st day after the operation. | For the postoperative period, the pain scores change was evaluated with the help of the visual analog scale (VAS) ranging from 0 (no pain) to 10 (most severe pain). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of Analgesics Taken by the Patients | Each patient was evaluated on the 1st, 2nd, 3rd, and 7th days after the operation. | — |
| Trismus | Each patient was evaluated in order to obtain measurements on the 1st, 2nd, 3rd, and 7th days after the operation. | Trismus was assessed by measuring the distance between the mesioincisal corner of the maxillary and mandibular right incisors while mouth was fully opened |
| Swelling on the cheek | Each patient was evaluated in order to obtain measurements on the 1st, 2nd, 3rd, and 7th days after the operation. | In order to record swelling, a modification of the tape measurement method |
Countries
Turkey (Türkiye)
Outcome results
None listed