Clubfoot
Conditions
Keywords
Ultrasound, Prenatal diagnosis, Congenital deformities, Perinatal outcome
Brief summary
Clubfoot is one of the most common birth defects, with a prevalence in Europe estimated between 1 and 4.5 for 1000 live birth. It is useful to distinguish the forms of isolated clubfoot, and the forms related to others morphological abnormalities (complex clubfoot). For the complex forms, the clubfoot can be integrated in a syndromic association, be the consequence of a serious harm of the central nervous system, be associate to a genetic musculo-skeletal disease or wether be associated to a karyotype abnormality. In those cases, the prognosis depends more about the associated morphological abnormalities that can be the beginning of a severe disability or incompatible with life or any anomaly of the karyotype that clubfoot itself. In case of several morphological abnormalities, to propose invasive samples with realization of a karyotype and chromosome analysis with CGH array is a consensual attitude. What the investigators should recommended to the parents in case of isolated form is less obvious and the question of antenatal investigations can not be answered clearly in the literature. Thus, the management of these patients may vary from one CPDP to another. This study project will make it possible to analyze the management offered to patients whose fetuses have club feet and to study the results of the various examinations carried out in order to adapt the prenatal counselling and to define the best diagnostic strategy to propose to the future parents.
Interventions
OTHERInvasive analysis (caryotype, CGH array)
Invasive analysis (caryotype, CGH array)
OTHERPrenatal management
Prenatal management
Sponsors
University Hospital, Montpellier
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 5 Years
Healthy volunteers
No
Inclusion criteria
* Congenital clubfoot uni or bilateral * Have been treated in the reference center Institut Saint Pierre, Plavas-les-flots, France
Exclusion criteria
\- Non confirmed clubfoot after birth
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Antenatal detection rate of clubfeet | At birth | Antenatal detection rate of clubfeet in percentage |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rate of refered for second-degree examination | At birth | Rate of refered for second-degree examination in percentage |
| Rate of invasive samples taken and their results | At birth | Rate of invasive samples taken and their results in percentage |
| Rate of files submitted to our reference center committee | At birth | Rate of files submitted to our reference center committee in percentage |
| Rate of isolated clubfoot among children followed for clubfoot | At birth | Rate of isolated clubfoot among children followed for clubfoot in percentage |
| Rate of consultation with geneticist | At birth | Rate of consultation with geneticist in percentage |
| Rate of consultation with a orthopedic surgeon | At birth | Rate of consultation with a orthopedic surgeon in percentage |
| Research rates of musculoskeletal genetic disease | At birth | Research rates of musculoskeletal genetic disease in percentage |
Countries
France
Outcome results
None listed