REM Sleep Behavior Disorder
Conditions
Brief summary
In this proposed study, the investigators aim to build up a large cohort of Rapid eye movement sleep behavior disorder (RBD) to study the etiology and risk factors of neurodegeneration.
Detailed description
REM sleep behavior disorder (RBD) is a parasomnia characterized by abnormal behavioral manifestations during REM sleep. Accumulating evidence suggests that RBD is implicated as an integral part of disease progress of α-synucleinopathy neurodegeneration, such as Parkinson's disease (PD) and dementia with Lewy bodies.Previous studies have identified a series of neurocognitive, autonomic, clinical and neurobiological markers for neurodegeneration in iRBD, such as olfactory dysfunction, color vision deficit, autonomic dysfunction, tonic EMG activity during REM sleep, and psychiatric disorder. However, the prevalence rate of RBD was relatively low and most of the RBD studies only have 100 or below cases. and there might be ethic differences in RBD which indicates that the findings from western countries might not be applicable to Chinese. In these regards, the investigators aimed to build up a large cohort of Rapid eye movement sleep behavior disorder (RBD) to study the etiology and risk factors of neurodegeneration.
Interventions
None listed
Sponsors
Chinese University of Hong Kong
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
Case: According to the ICSD-3 for the diagnosis of RBD 1. Sleep talking or complex movement during sleep; 2. Such movement was recorded by video PSG (AV-PSG) during REM sleep or according to history the movements were occurred during REM; 3. REM sleep without atonia (RWA) during PSG monitoring; 4. This abnormal phenomenon cannot be explained by other sleep disorder, psychiatric disease, drug or substance abuse. Control: Age and gender matched with consent 1. No RBD symptoms and PSG characteristics; 2. No neurological symptoms or diseases, MRI scan will be employed to exclude brain pathology; 3. No narcolepsy or hypersomnia, ruled out by multiple sleep latency test; 4. No history of mental illnesses or use of antidepressants.
Exclusion criteria
1\. Subjects who refused to join the cohort.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Risk factors for neurodegenerative diseases in rapid eye movement sleep behavior disorder. | 1 hour | Risk factors for neurodegenerative diseases were investigated in rapid eye movement sleep behavior disorder by questionnaires, including general information, life history, occupational history and family history. |
| Changes of neurocognitive biomarkers for neurodegenerative diseases in rapid eye movement sleep behavior disorder. | Baseline and biennial follow-up, up to 20 years | Based on the large cohort of RBD, the investigators aim to study the etiology and the progression of neurocognitive biomarkers for neurodegenerative diseases in rapid eye movement sleep behavior disorder by clinical assessment, including MoCA, olfactory dysfunction, color vision deficit and so on. |
| Changes of autonomic dysfunctions for neurodegenerative diseases in rapid eye movement sleep behavior disorder. | Baseline and biennial follow-up, up to 20 years | Autonomic dysfunctions are also biomarkers for neurodegenerative diseases, the investigators aim to observe the changes of autonomic dysfunctions, including constipation, orthostatic hypotension and so on. |
| Changes of REM-related EMG activity (REMREEA) and motor activity in rapid eye movement sleep behavior disorder. | Baseline and biennial follow-up, up to 20 years | The percentage of REM-related EMG activity (REMREEA) is the most reliable and valid marker in differentiating patients with RBD from normal controls. Both REMREEA and significant motor activity were recorded by video-polysomnography in rapid eye movement sleep behavior disorder. |
Countries
Hong Kong
Contacts
Primary ContactJihui Zhang, PhD
Outcome results
None listed