Chronic Kidney Disease, Older, Sarcopenia
Conditions
Keywords
sarcopenia, chronic kidney disease, older
Brief summary
Older patients with chronic renal failure suffer from sarcopenia. Loss of muscle function is associated with increased morbidity and mortality. Currently few treatment are available. The aim of this study is to evaluate the impact of physical rehabilitation in this population on muscle performance and quality of life.
Interventions
BEHAVIORALPhysical rehabilitation
It will benefit from an initial and final geriatric assessment, an initial dietary balance and a personalized treatment in physical activities adapted for 3 months by an Educator in Adapted Physical Activities.
Sponsors
Hospices Civils de Lyon
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
70 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* man or woman * age over 70 years * CKD stage 3B, 4 or 5 or a DFG \<45ml / min according to CKD-EPI formula * an SPPB (Short Physical Performance Battery test )\<10 * having received a complete and loyal information and having given his written and informed consent. * ability to rehabilitate
Exclusion criteria
* Subject not presenting previous inclusion criteria * General condition not compatible for the realization of physical rehabilitation * Patient protected under the terms of the law. * Inability to respect the follow-up of the study for geographical, social or psychological reasons. * depression or other psychiatric disorder * Refusal to participate in the study * Absence of affiliation to the social security system * Subject in a exclusion period of an other study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from Baseline distance travelled (in meters) during the 6-minute walking distance (6MWD) test (muscular performance), at 3 months | Baseline and 3 months |
Secondary
| Measure | Time frame |
|---|---|
| Nutritional parameter: Prealbuminemia | Baseline,3 and 6 months |
| Nutritional parameter: Body mass index | Baseline,3 and 6 months |
| Nutritional parameter: Albuminemia | Baseline,3 and 6 months |
| Muscle strength evaluated by Hand Grip strength test | Baseline,3 and 6 months |
| Quality of life evaluated by the questionnaire SF-36 (36-item medical outcomes study Short-Form health survey) | Baseline,3 and 6 months |
| Nutritional parameter: bioimpedancemetry | Baseline,3 and 6 months |
Countries
France
Contacts
Primary ContactLaëtitia KOPPE, MD
Outcome results
None listed