Major Depression
Conditions
Keywords
Major Depression, EEG, Eye Tracker, fMRI, MRI, Resting State Connectivity, Cognition
Brief summary
This project will combine the data collected from EEG, Eye tracking, structural and functional MRI scans and neuropsychological performance from patients with major depression receiving SSRI treatment. The purpose of this research is to predict the success of the SSRI treatment and to categorize patients into sub-groups according to similar patterns of brain activation to personalize treatment.
Detailed description
Major depression is a mood disorder affecting 350 million people worldwide. The disorder is characterized by depressed mood, anhedonia, decreased quality of life, deficits in cognitive functions and even suicide thoughts. Treatment of depression is often a long process and includes taking different types and quantities of medications. Therefore, there is a need to predict the success of the SSRI treatment. Our research will examine the outcomes of the combined technologies: BNA (EEG), Eye-tracker, structural and functional MRI scans and neuropsychology tasks in patients with depression while receiving SSRI treatment. The purpose of the research is to track biomarkers and other measures, which will allow predicting the SSRI treatment's success within 4 weeks instead of 8 weeks. In addition, the investigators will attempt to categorize patients into different subgroups according to their brain activation and eye movements. This division into subgroups may contribute to the understanding of the mechanisms that account for the responsiveness to SSRI treatment and to the possibility of targeting patients with depression towards a particular treatment. From this research, the investigators aim to personalize the treatment of depression, make it more efficient and reduce the amount of time for the patient to reach an optimal responsiveness.
Interventions
DEVICESIEMENS PRISMA MRI
Collect data on brain activation from different methods
Sponsors
Sheba Medical Center
Hebrew University of Jerusalem
ElMindA Ltd
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
1. Patients 18-65 years old 2. Male and female 3. Ability to comprehend and sign informed consent 4. DSM-5 diagnosis with MINI 7.0.2 (healthy subjects need to be ruled out) Inclusion Criteria for patients with depression: 1. DSM-5 diagnosis 2. 0-2 failed treatments 3. Patients which will start SSRI treatment
Exclusion criteria
1. unconsciousness 2. Pregnancy or nursing 3. Cardiovascular instability 4. Metabolic instability (water, electrolytes, sugar) 5. Fever or evidence of microbiological pollutant 6. Deafness or blindness 7. Schizophrenia 8. Addiction disorders 9. Eating disorders 10. Bi-polar disorder 11. Cognitive deficits 12. Start a new psychotherapy during the research 13. Unable to enter the MRI scanner
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| EEG responses to cognitive tasks in combination with the Eye-tracker Device. | 2 years | Categorize patients into subgroups according to combined measures of EEG and Eye |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Examine correlations between the different methods | 2 years | Examine correlations between the different methods EEG, Eye-tracking and fMRI |
| EEG brain activation to cognitive tasks | 2 years | Categorize patients into subgroups according to similar brain activity |
| Resting state connectivity analysis | 2 years | Examine the difference in resting state connectivity between the groups. |
| Examine MRI structural changes | 2 years | Compare structural changes between the groups (patients with depression, healthy subjects). |
| Cognitive scores on CANTAB (computerized cognitive assessments) | 2 years | Examine the difference in responses to different cognitive exams between the groups |
| Eye-tracking tasks | 2 years | Categorize patients into subgroups according to similar patterns of eye movements. |
Countries
Israel
Contacts
Primary ContactRevital Amiaz
Backup ContactLiran Korine
Outcome results
None listed