Unexplained Female Infertility
Conditions
Brief summary
This study will add: Finding out an association between Protein S activity and unexplained female infertility. Aim: Study hypothesis: In women with unexplained infertility protein S activity may be low. Study question: In women with unexplained infertility does protein S activity low?. This study aims to assess the activity of protein S activity in women with unexplained infertility. Objectives: The main objective of this study is: To determine the prevalence of Protein S activity with unexplained female infertility and to compare its prevalence in fertile women among women attending outpatient clinics at Ain Shams University Maternity Hospital.
Detailed description
1. Type of Study: Case Control Study. 2. Study Setting: Ain Shams University Maternity Hospital: outpatient Infertility clinic and outpatient gynecology clinic. 3. Study Population: The study will include women with unexplained infertility (Group 1; cases) and fertile women who got pregnant and delivered at least once in the previous year with no history of recurrent abortions nor history of secondary infertility (Group 2; control). Group 1: Will include 30 women with unexplained primary infertility; will be recruited from the outpatient infertility clinic. Group 2; another 30 fertile women who got pregnant and delivered at least once in the previous year with no history of recurrent abortions; will recruited from outpatient gynecology clinic as control. According to inclusion and exclusion criteria listed below. Inclusion criteria: 1. Age: 18 - 35 years old. 2. Normal husband's semen analysis, (WHO criteria): 1. Count ≥ 15 million/ml. 2. Motility: ≥ 40% 3. Morphology: ≥ 4% normal morphology. 3. Documented ovulation. 4. Normal Follicle Stimulating Hormone, Luteinizing Hormone, Thyroid Stimulating Hormone, serum prolactin. 5. Patent Fallopian tubes. 6. Normal uterine cavity. Exclusion criteria: 1. Patients aged less than 18 years or more than 35 years old. 2. Secondary infertility 3. Presence of male factor infertility 4. Anovulatory cycles. 5. Tubal block; Tubal disease is an important cause of infertility and should be specifically excluded. 6. Medical disorder that might affect pregnancy (e.g.: Diabetes, Thyroid dysfunction) 7. Patients with recurrent abortion.
Interventions
DIAGNOSTIC_TESTProtein S activity
Intravenous blood sample
Sponsors
Ain Shams Maternity Hospital
Esraa Gamal Ahmed
Study design
Observational model
CASE_CONTROL
Time perspective
OTHER
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
1. Age: 18 - 35 years old. 2. Normal husband's semen analysis, (WHO criteria): 1. Count ≥ 15 million/ml. 2. Motility: ≥ 40% 3. Morphology: ≥ 4% normal morphology. 3. Documented ovulation. 4. Normal Follicle Stimulating Hormone, Luteinizing Hormone, Thyroid Stimulating Hormone, serum prolactin. 5. Patent Fallopian tubes. 6. Normal uterine cavity. \-
Exclusion criteria
1. Patients aged less than 18 years or more than 35 years old. 2. Secondary infertility 3. Presence of male factor infertility 4. Anovulatory cycles. 5. Tubal block; Tubal disease is an important cause of infertility and should be specifically excluded. 6. Medical disorder that might affect pregnancy (e.g.: Diabetes, Thyroid dysfunction) 7. Patients with recurrent abortion. -
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Protein S activity | six months | venous blood sample |
Outcome results
None listed