Metabolism and Nutrition Disorder, Metabolism Disorder, Lipid, Rhythm Nodal
Conditions
Keywords
biological rhythm, metabolism, hormone, lipid, bile acids, obesity
Brief summary
The circadian regulation in mammals have been known for a long time. A special group of clock genes, organized in feedback loops, are responsible for the circadian regulation in both the SCN and peripheral organs. The central clock is mainly entrained by the light-dark cycle, while the peripheral ones in organs such as liver and intestine, are more influenced by the feeding-fasting cycles. The coordination of central and peripheral clocks is thought to be essential in the maintenance of physiological homeostasis.This study aim to investigate the association between biological rhythm and metabolism.
Interventions
None listed
Sponsors
Shandong Provincial Hospital
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Male or female； * Aged of 18 to 30 years old;
Exclusion criteria
* Presence of pituitary/hypothalamic disorders, polycystic ovarian syndrome， thyroid disorders, hypertension, malignant tumor, cardiac insufficiency，hepatic or renal insufficiency, gastrointestinal disorders and acute infection; * Receiving psychotropic or hormonal medications including hormonal contraception and hormone therapies; * Taking lipid-lowering agents or hypoglycemic agents and other drugs that known to influence cardiovascular health; * Pregnancy or lactation women; * Obviously poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| circadian rhythms of serum lipid levels （the change of serum lipid levels within 24 hours） | Measured at baseline, and every 10 years during the 40-year follow-up period |
Secondary
| Measure | Time frame |
|---|---|
| circadian rhythms of gonadal hormone and gonadotropin（the change of gonadal hormone and gonadotropin within 24 hours） | Measured at baseline, and every 10 years during the 40-year follow-up period |
| circadian rhythms of serum total bile acids（the change of serum total bile acids within 24 hours） | Measured at baseline, and every 10 years during the 40-year follow-up period |
| change in urine metabolite | Measured at baseline, and every 10 years during the 40-year follow-up period |
| change in intestinal flora | Measured at baseline, and every 10 years during the 40-year follow-up period |
| change in sperm quality | Measured at baseline, and every 10 years during the 40-year follow-up period |
Countries
China
Contacts
Primary ContactLing Gao
Outcome results
None listed