Aneurysmal Disease, Carotid Artery Diseases, Peripheral Artery Disease, Vascular Diseases
Conditions
Keywords
Vascular Diseases, Peripheral Artery Disease
Brief summary
An observational cohort study of the frailty of vascular surgery patients undergoing intervention and their outcomes.
Detailed description
Vascular surgical operations are major procedures with significant associated morbidity and mortality. Frailty is a major factor influencing surgical outcome, but the effect on morbidity/mortality and quality of life is poorly understood in vascular surgery. Activity levels play a significant role in frailty and in pre-intervention preparation. It is anticipated that as frailty levels increase, activity levels decrease. It is hypothesised that vascular surgery patients suffer from a high prevalence of frailty and that increasing frailty will lead to increased morbidity and mortality and decreased quality of life. This initial study will provide the foundations to identify targets for improvement in degree of frailty, appropriateness for surgery and outcome. This project aims to: Assess and quantify the prevalence of frailty as well as recording activity levels in the vascular surgery patient cohort Explore the impact of frailty and pre-op activity on surgical outcomes in the vascular surgical patient cohort to guide surgical treatments as well as future studies aimed at improving frailty and activity and thereby quality of life. Identification of an appropriate metric of frailty for this population group to include activity, is a secondary aim of this proposal.
Interventions
OTHERQuestionnaire
Quality of life and frailty questionnaires
Sponsors
Imperial College Healthcare NHS Trust
Imperial College London
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. All patients attending for aortic aneurysm repair, carotid artery surgery and lower limb revascularisation under the care of the Vascular Surgery team 2. Willing and able to give informed written consent
Exclusion criteria
1. Those unable to give informed written consent 2. Those \<18 years of age 3. In the opinion of the investigator unable or unwilling to comply with the requirements of the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between electronic Frailty Index and survival and complication rate. | 6 months | Survival and rate of complication correlated with the pre-operative frailty score (electronic Frailty Index). |
| Correlation between Q Mortality Index and survival and complication rate. | 6 months | Survival and rate of complication correlated with the pre-operative frailty score (Q Mortality Index). |
| Correlation between ACS Risk Calculator Score and survival and complication rate. | 6 months | Survival and rate of complication correlated with the pre-operative frailty score (ACS Risk Calculator). |
| Correlation between V-Possum and survival and complication rate. | 6 months | Survival and rate of complication correlated with the pre-operative frailty score (V-Possum). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Activity Levels Pre and Post Surgery as measured by the General Practice Physical Activity Questionnaire | 6 months | General Practice Physical Activity Questionnaire will be used to assess patient reported activity before and after surgery. |
| Quality of Life Pre and Post Surgery as measure by the EuroQoL EQ-5D questionnaire | 6 months | EuroQol EQ-5D Quality of Life questionnaire will be used to assess patient reported quality of life before and after surgery. |
Countries
United Kingdom
Contacts
Primary ContactTristan R Lane, PhD FRCS
Outcome results
None listed