Evaluation of Novel Lung Function Parameters in Patients With Pulmonary Hypertension (PH)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03667794

Enrollment

Registered

2018-09-12

Start date

2015-07-01

Completion date

2017-07-31

Last updated

2018-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary Hypertension

Brief summary

Little is known about affection of small airways in patients with pulmonary hypertension as well as the ideal diagnostic approach. The investigators therefore aimed to evaluate novel or not widely used lung function tests for the evaluation of airway function in patients with PH.

Interventions

DIAGNOSTIC_TESTmultiple breath washout

measurement of ventilation heterogeneity

DIAGNOSTIC_TESTbody plethysmography

measurement of conventional lung function parameters

DIAGNOSTIC_TESTimpulse oscillometry

measurement of central and peripheral airway resistance

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 99 Years

Healthy volunteers

Yes

Inclusion criteria

* known or first diagnosis of PH

Exclusion criteria

* inability to perform lung function testing * unable or unwilling to participate

Design outcomes

Primary

Measure	Time frame	Description
LCI	30 minutes	between-group difference in lung clearance index (LCI)
D5-20	30 minutes	between-group difference in frequency dependence of resistance (D5-20)

Secondary

Measure	Time frame	Description
Discrimination small airway resistance	30 minutes	Evaluation of discriminative capability of impulse oscillometry
Discrimination ventilation heterogeneity	30 minutes	Evaluation of discriminative capability of multiple breath washout

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026