Breast Cancers, Ovarian Cancers
Conditions
Keywords
BRCA gene mutation
Brief summary
Cohort of subjects carrying a BRCA gene mutation: genetic predispositions to breast and ovarian cancers
Detailed description
Cohort of subjects carrying a BRCA gene mutation: genetic predispositions to breast and ovarian cancers
Interventions
OTHERQuestionnaires
standardized data collection and 10-year prospective follow-up
Sponsors
UNICANCER - Le Groupe génétique et cancer (GGC)
Institut Paoli-Calmettes
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Woman or man, with or without cancer, carrying a deleterious BRCA1/BRCA2 mutation, aged 18 years and over. 1. Woman with or without breast cancer or ovarian cancer at baseline. 2. Man with or without breast cancer at baseline. 2. Signed consent to participation 3. Affiliation to a social security regimen, or beneficiary of such a regimen.
Exclusion criteria
1. A person of legal age subject to a legal protection measure, or unable to express consent. 2. Impossibility to submit to the follow-up of the test for geographical, social or psychological reasons
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of breast and / or ovarian cancer during subject lifetime | 10 years | risk that a subject with a mutation develops breast and / or ovarian cancer during his lifetime, assessed by epidemiologic questionnaires (carcinologic events). |
Countries
France
Contacts
Primary ContactDominique GENRE, MD
Backup ContactMargot BERLINE, MSc, MBA
Outcome results
None listed