Alzheimer Disease, Dementia
Conditions
Keywords
LGBT
Brief summary
The lack of efficacious research-based interventions for sexual and gender minority (SGM) older adults living with Alzheimer's disease and other dementias, combined with the heightened risk of cognitive impairment in this population, presents a significant public health problem. SGM older adults are at elevated risk of social isolation and experience significant barriers to healthcare access. Existing interventions for older adults with dementia have been found to be effective for caregiving dyads. Yet SGM older adults, compared to heterosexuals, are significantly less likely to be married or to have biological family members to support them. A significant proportion of SGM older adults living with dementia have no caregiver or care network. The goal of the proposed research is to design and pilot test the cultural appropriateness, acceptability, and feasibility of an innovative translation of a personalized care network-RDAD (Reducing Disability in Alzheimer's Disease) to support those living with dementia without a family caregiver, directly addressing unique SGM-specific risk factors.
Detailed description
We will address the following aims: Aim 1. Develop a personalized care network-RDAD intervention suitable for SGM older adults living with dementia without caregivers. Aim 2. Implement a preliminary randomized controlled trial (RCT) of 30 participants with 2 arms (routine medical care vs. the personalized care network-RDAD approach) to assess the acceptability, feasibility, and initial efficacy of the intervention.
Interventions
BEHAVIORALPersonalized care network
The Personalized care network intervention includes exercise training for participant with dementia and behavioral management training for addressing challenges.
Sponsors
National Institute on Aging (NIA)
University of Washington
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
This study will utilize a 2-group randomized controlled trial design including 2 assessments, i.e. a pre-treatment and a post-treatment.
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age at enrollment is 50 years of age or older * Self-identify as LGBT (or sexual or gender non-binary or same sex sexual behavior) * Have early stage dementia, including Alzheimer's disease or needs help with complex daily activities * Living in the community, not in a care facility.
Exclusion criteria
* Known terminal illness (with death anticipated within the next 12 months) * Hospitalization for a psychiatric disorder in the 12 months prior to baseline * Have more than early stage dementia * Any physical limitations/chronic conditions preventing participation in an exercise program.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Physical Activity | Baseline (pre-treatment) and 7 weeks (post-treatment) | Minutes spent on exercising per week in the past month were calculated from the following two questions: (1) How much time did you spend on exercises (hours per day) on a typical day during the last month; (2) How many days did you spend on exercises during the last month. |
| Change in Physical Functioning | Baseline (pre-treatment) and 7 weeks (post-treatment) | Physical Functioning subscale of the Medical Outcomes Study 36-Item Short Form (SF-36) consists of 10 items and measures how much participants' health status limits their activities including walking, climbing, lifting, and bathing or dressing oneself, based on self-reports. Each item is measured a 3-point scale (1 = Yes, limited a lot; 2 = Yes, limited a little; 3 = No, not limited at all), then recoded into 0, 50, and 100, respectively. The recoded scores are averaged to generate a summary score with its possible range from 0 to 100. Higher scores indicate better physical functioning. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Quality of Life | Baseline (pre-treatment) and 7 weeks (post-treatment) | Quality of Life in Alzheimer's Disease (QOL-AD) is a 13-item scale that measures participant's self-reported feelings about different aspects of life including energy, mood, living situation, memory, family, friends, ability, and money. Each item has a 4-point response scale (1 = poor; 2 = fair; 3 = good; 4 = excellent). The summary score is a sum of the 13 items with its possible range from 13 to 52. Higher scores indicate higher quality of life. |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Personalized Care Network 9 60-minute virtual sessions for 6 weeks plus personalized exercise coaching once a week for 6 weeks
Personalized care network: The Personalized care network intervention includes exercise training for participant with dementia and behavioral management training for addressing challenges. | 14 |
| Routine Medical Care No intervention | 15 |
| Total | 29 |
Withdrawals & dropouts
| Period | Reason | FG000 | FG001 |
|---|---|---|---|
| Overall Study | participant grieving over recent death of parent | 1 | 0 |
Baseline characteristics
| Characteristic | Routine Medical Care | Total | Personalized Care Network |
|---|---|---|---|
| Age, Continuous | 68.8 years STANDARD_DEVIATION 2 | 68.6 years STANDARD_DEVIATION 1.3 | 68.4 years STANDARD_DEVIATION 1.8 |
| Ethnicity (NIH/OMB) Hispanic or Latino | 3 Participants | 4 Participants | 1 Participants |
| Ethnicity (NIH/OMB) Not Hispanic or Latino | 12 Participants | 25 Participants | 13 Participants |
| Ethnicity (NIH/OMB) Unknown or Not Reported | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) American Indian or Alaska Native | 0 Participants | 1 Participants | 1 Participants |
| Race (NIH/OMB) Asian | 1 Participants | 1 Participants | 0 Participants |
| Race (NIH/OMB) Black or African American | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) More than one race | 2 Participants | 5 Participants | 3 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 1 Participants | 1 Participants | 0 Participants |
| Race (NIH/OMB) White | 11 Participants | 21 Participants | 10 Participants |
| Sex: Female, Male Female | 4 Participants | 9 Participants | 5 Participants |
| Sex: Female, Male Male | 11 Participants | 20 Participants | 9 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | 0 / 15 | 0 / 15 |
| other Total, other adverse events | 0 / 15 | 0 / 15 |
| serious Total, serious adverse events | 0 / 15 | 0 / 15 |
Outcome results
Primary
Change in Physical Activity
Minutes spent on exercising per week in the past month were calculated from the following two questions: (1) How much time did you spend on exercises (hours per day) on a typical day during the last month; (2) How many days did you spend on exercises during the last month.
Time frame: Baseline (pre-treatment) and 7 weeks (post-treatment)
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Personalized Care Network | Change in Physical Activity | Unadjusted mean at baseline | 227 minutes per week | Standard Error 69 |
| Personalized Care Network | Change in Physical Activity | Unadjusted mean at 7 weeks | 380 minutes per week | Standard Error 105 |
| Routine Medical Care | Change in Physical Activity | Unadjusted mean at baseline | 282 minutes per week | Standard Error 129 |
| Routine Medical Care | Change in Physical Activity | Unadjusted mean at 7 weeks | 232 minutes per week | Standard Error 76 |
Primary
Change in Physical Functioning
Physical Functioning subscale of the Medical Outcomes Study 36-Item Short Form (SF-36) consists of 10 items and measures how much participants' health status limits their activities including walking, climbing, lifting, and bathing or dressing oneself, based on self-reports. Each item is measured a 3-point scale (1 = Yes, limited a lot; 2 = Yes, limited a little; 3 = No, not limited at all), then recoded into 0, 50, and 100, respectively. The recoded scores are averaged to generate a summary score with its possible range from 0 to 100. Higher scores indicate better physical functioning.
Time frame: Baseline (pre-treatment) and 7 weeks (post-treatment)
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Personalized Care Network | Change in Physical Functioning | Unadjusted score at baseline | 66.1 score on a scale | Standard Error 6.7 |
| Personalized Care Network | Change in Physical Functioning | Unadjusted score at 7 weeks | 73.2 score on a scale | Standard Error 7.3 |
| Routine Medical Care | Change in Physical Functioning | Unadjusted score at baseline | 73.0 score on a scale | Standard Error 6.1 |
| Routine Medical Care | Change in Physical Functioning | Unadjusted score at 7 weeks | 72.0 score on a scale | Standard Error 6.2 |
Secondary
Change in Quality of Life
Quality of Life in Alzheimer's Disease (QOL-AD) is a 13-item scale that measures participant's self-reported feelings about different aspects of life including energy, mood, living situation, memory, family, friends, ability, and money. Each item has a 4-point response scale (1 = poor; 2 = fair; 3 = good; 4 = excellent). The summary score is a sum of the 13 items with its possible range from 13 to 52. Higher scores indicate higher quality of life.
Time frame: Baseline (pre-treatment) and 7 weeks (post-treatment)
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Personalized Care Network | Change in Quality of Life | Unadjusted score at baseline | 30.9 score on a scale | Standard Error 2.3 |
| Personalized Care Network | Change in Quality of Life | Unadjusted score at 7 weeks | 32.7 score on a scale | Standard Error 3.3 |
| Routine Medical Care | Change in Quality of Life | Unadjusted score at baseline | 32.2 score on a scale | Standard Error 1.8 |
| Routine Medical Care | Change in Quality of Life | Unadjusted score at 7 weeks | 32.0 score on a scale | Standard Error 1.5 |