Postoperative Residual Curarization
Conditions
Keywords
Muscle Relaxation
Brief summary
The primary objective of this study is to evaluate the incidence of postoperative residual curarization, as defined by a train-of-four \<90%, upon postanaesthesia care unit arrival. Anesthetists tend to use train-of-four monitoring in the operating theatre to interpret muscle tone. Train-of-four monitoring is a widely used term for the peripheral nerve stimulation used in neuromuscular blockade monitoring. Hypothesizing a change in our practice since 2006-2012 (Cammu G, Anesth Analg 2006; 102: 426-9 and Cammu G, Anaesth Intensive Care 2012; 40: 999-1006), residual neuromuscular block as well as the use of intraoperative neuromuscular transmission monitoring and reversal of neuromuscular blocking agents will again be prospectively evaluated in 2018. The present study aims to compare these three periods (2006-2012-2018) in terms of management of neuromuscular block in the operating room and to look for a relationship with the incidence of postoperative residual curarization.
Interventions
The acceleromyographic responses of the adductor pollicis muscle as percent of the train-of-four (TOF%) on stimulation of the ulnar nerve by means of the TOFscan neuromuscular transmission monitor (iDMed, Marseille, France).
Sponsors
Onze Lieve Vrouw Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 18 years of age or older; * Informed consent signed; * Admission for elective surgery; * Administration of non-depolarizing neuromuscular blocking agents during surgery; * Tracheal intubation
Exclusion criteria
* Evidence of renal, hepatic, metabolic, and/or neuromuscular disorders * Ejection fraction \<20% * Admission for emergency surgery; or cardiothoracic surgery * Reoperation during the same hospital admission
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of postoperative residual curarisation | Immediately after the patients' arrival in the post-anesthesia care unit (<5 min after arrival), two consecutive neuromuscular transmission measurements (separated by 15 s) will be obtained, and the average of the 2 values will be recorded. | Incidence of postoperative residual curarisation defined by a train-of-four (TOF) ratio \< 0,9 at post-anesthesia care unit arrival |
Countries
Belgium
Outcome results
None listed