Diabetic Macular Edema of Both Eyes (Diagnosis), Diabetic Retinopathy Visually Threatening
Conditions
Brief summary
To describe the design, methodology and baseline characteristics of the Shanghai Cohort study of Diabetic Eye disease (SCODE) study, a community-based study to determine the prevalence and impact of diabetic eye disease, especially diabetic retinopathy (DR), in adults with diabetes living in Shanghai.
Detailed description
The Shanghai Cohort study of Diabetic Eye disease (SCODE) was a three-year community-based study to carry out a regular ocular health screening and epidemiological analysis for diabetic eye disease in the approximately 8,000 middle-aged and elderly people with diabetes in Shanghai. Through this study, we hope to understand the prevalence, epidemic trend and the features of risk factors distribution on diabetic eye disease, especially on DR. Meanwhile, our aims also included estimating the ocular fundus changes and visual impairment associated with different grade of DR. Furthermore, the aim of the present study was to investigate the association between serum and urine biochemical parameters and DR.
Interventions
BEHAVIORALDiabetic eye disease screening
Community-based, prospective cohort study from three consecutive years (2016 to 2018) to determine the prevalence and impact of diabetic eye disease, especially diabetic retinopathy (DR), in adults with diabetes living in Shanghai.
Sponsors
Shanghai Eye Disease Prevention and Treatment Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
35 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults with diabetes aged 35 years and above; under archives management; residing in Shanghai.
Exclusion criteria
* All the study participants have difficulties of mobility or communication.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence and incidence rate of diabetic eye disease | December 31, 2018 | SCODE was performed to evaluate the prevalence and rate of new cases of diabetic eye disease, especially DR, in a three-year community-based cohort study for the people with diabetes, and to identify the associated factors related with diabetic eye disease. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Grading of DR | December 31, 2018 | Fundus changes were evaluated on non-mydriatic fundus photography and slit-lamp examination. Meanwhile, we will estimate the fundus changes associated with different grade of DR. |
| Retinal and choroidal thickness | December 31, 2018 | Retinal and choroidal thickness were evaluated on SS-OCT. |
| Retinal blood flow | December 31, 2018 | Retinal blood flow were evaluated on SD-OCTA. |
| Blood biochemistry indexes | December 31, 2018 | Blood samples were used for testing, including glucose, glycosylated hemoglobin (HbA1C), serum lipids, etc. |
| Urine biochemistry indexes | December 31, 2018 | Urine samples were used for testing urine albumin and creatinine. |
| Visual impairment | December 31, 2018 | Main Cause of visual impairment were determined by two ophthalmologists based on the ophthalmic examinations and reported history. Moreover, we will evaluate the association between the visual impairment and different grade of DR. |
Outcome results
None listed