Immunologic Markers
Conditions
Brief summary
This study aim to describe dynamics of immunologic markers C1 inhibitor, C3, C4 during the delivery in order to improve early diagnostics of obstetric emergencies, especially with immune etiology.
Detailed description
Our prospective observational study will explore the differences between dynamics of the complement components C1 inhibitor, C1 inhibitor activity, C3, C4 during the labour in a group of women with physiologic pregnancy and in a group with a risk of complications (pre-eclampsia, HELLP syndrome, placenta praevia, placental abruption, IUGR, previous post partum hypotony). We will focus on women undergoing the Caesarean delivery. We will also measure D vitamin levels and ACE levels and search for some contexts.
Interventions
DIAGNOSTIC_TESTBlood sampling
differences between dynamics of the complement components C1 inhibitor, C1 inhibitor activity, C3, C4 during the labour in a group of women with physiologic pregnancy and in a group with a risk of complications (pre-eclampsia, HELLP syndrome, placenta praevia, placental abruption, IUGR, previous post partum hypotony).
Sponsors
Brno University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
15 Years to 50 Years
Inclusion criteria
* Pregnant women undergoing the Caesarean delivery * Signed informed consent
Exclusion criteria
* Previous hepatitis or other hepatocyte damage
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in levels of total C1 inhibitor | 30 minutes before and 30 minutes after delivery | Chenge in levels of total C1 inhibitor |
| Change in levels of CRP levels | 30 minutes before and 30 minutes after delivery | Change in levels of CRP levels |
| Change in levels of D vitamin levels | 30 minutes before and 30 minutes after delivery | Change in levels of D vitamin levels and it's relationship to pre-eclampsia |
| Change in levels of ACE levels | 30 minutes before and 30 minutes after delivery | Change in levels of ACE levels |
| Change of C1 inhibitor activity | 30 minutes before and 30 minutes after delivery | Change of C1 inhibitor activity |
| Change in levels of total C3 | 30 minutes before and 30 minutes after delivery | Change in levels of total C3 |
| Change in levels of total C4 | 30 minutes before and 30 minutes after delivery | Change in levels of total C4 |
Countries
Czechia
Outcome results
None listed