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Oculocardiac Reflex Brain Wave Monitor

The Oculocardiac Reflex Influenced at Different Levels of Brain Wave Monitoring

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03663413
Acronym
OCRBIS
Enrollment
188
Registered
2018-09-10
Start date
2009-08-27
Completion date
2013-11-21
Last updated
2020-10-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bradycardia, Strabismus

Brief summary

Oculocardiac reflex during routine strabismus surgery was prospectively observed in association with routine brain wave monitoring. Providence Hospital institutional review board (IRB) approved this observational study without need for consent.

Detailed description

Introduction: The oculocardiac reflex (OCR), bradycardia that occurs during strabismus surgery, is blocked by anticholinergics and enhanced by opioids and dexmedetomidine. Two recent studies suggest that deeper inhalational anesthesia monitored by bispectral index (BIS) protects against OCR; the investigators wondered if our data correlated similarly. Methods: In an ongoing, prospective study of OCR elicited by 10-second, 200 gram square-wave traction on extraocular muscles (EOM) from 2009 to 2013, anesthetic depth was estimated in cohorts using either BIS or Narcotrend monitors. The depth of anesthesia was deliberately varied between first and second EOM tested.

Interventions

DEVICEnon-invasive monitor

cutaneous EEG monitor

Sponsors

Alaska Blind Child Discovery
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
3 Months to No maximum
Healthy volunteers
No

Inclusion criteria

* all

Exclusion criteria

* those receiving anticholinergic medications

Design outcomes

Primary

MeasureTime frameDescription
heart rate changeintraoperative 10 secondsbradycardia with extra ocular muscle tension

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 3, 2026