Broken Heart Syndrome, Tako-tsubo Cardiomyopathy, Takotsubo Cardiomyopathy
Conditions
Brief summary
Takotsubo syndrome is a condition which mimics acute myocardial infarction, and is diagnosed in 1.5% to 2.2% of patients referred to hospital with suspected acute coronary syndrome. It is also known as broken heart syndrome, takotsubo cardiomyopathy, stress cardiomyopathy and apical ballooning cardiomyopathy, among other names. The pathogenesis of this disorder is not well understood. Possible mechanisms include catecholamine excess, coronary artery spasm, microvascular dysfunction, among others. This is a multicenter, nation-wide, observational study of patients who were previously diagnosed with takotsubo syndrome. The investigators aim to use this registry to help plan and carry out further studies and to improve understanding of the pathophysiologic mechanisms of this syndrome. In addition participants will be followed for events, and to monitor quality of life and stress.
Detailed description
Patients are eligible to participate if they are aged 18 years or older and carry a physician confirmed diagnosis of takotsubo syndrome. Patients with a history of takotsubo syndrome will be identified via physician referral, Epic search and patient self-referral. Patients may register directly through our registry website at www.nyulmc.org/brokenheartstudy or via direct contact with the study team via e-mail or telephone. Following completion of a research authorization form and collection of medical records, study team will confirm the diagnosis of takotsubo syndrome. Data will be collected including contact information, medical history, data on the takotsubo event(s) including physician records and all relevant imaging. Participants will also be asked quality of life questionnaires and will be followed every 4 months for events.
Interventions
None listed
Sponsors
NYU Langone Health
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 110 Years
Healthy volunteers
No
Inclusion criteria
* Physician diagnosis of takotsubo syndrome * Age\>18 years
Exclusion criteria
\- Lack of capacity to provide informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Major Adverse Cardiac Events | up to 10 years | Medical record review and patient report of repeat takotsubo event, MI, heart failure, unstable angina, chest pain ER visit, cardiovascular death, stroke |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Quality of life assessed using the Patient Reported Outcome Measurement Information System (PROMIS-10) questionnaire | every four months up to 10 years | Measure of quality of life |
| Anxiety is assessed using the Hospital Anxiety and Depression Scale (HADS-A) | every four months up to 10 years | Measure of anxiety |
| Depression assessed using the Patient Health Questionnaire (PHQ-9) | every four months up to 10 years | Measure of depression |
| Perceived stress is measured using the Perceived Stress Scale (PSS-10) | every four months up to 10 years | Measure of perceived stress |
Countries
United States
Contacts
Primary ContactHarmony Reynolds, MD
Backup ContactAnais Hausvater, MD
Outcome results
None listed