Circadian Dysregulation, Inflammatory Bowel Diseases
Conditions
Brief summary
patients 6-25 years old upon diagnostic evaluation will be recruited . study population will comprise of two groups: newly diagnosed IBD patients/ Celiac disease and healthy controls. upon enrollment, subjects will fill out sleeping habits questioners, demographic data, medical history. blood samples will be drawn for CRP and clock gene expression in systemic WBC. intestinal biopsies will be snap frozen for clock gene extraction and amplification only for patients with IBD.
Interventions
OTHERno intervention performed- observational only
no intervention performed- observational only
Sponsors
Tel-Aviv Sourasky Medical Center
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
6 Years to 25 Years
Healthy volunteers
No
Inclusion criteria
* IBD or celiac patients with a confirmed diagnosis, recruited upon diagnosis. * Both male and female * Age 6-25 years * Medically treated for IBD in our institute.
Exclusion criteria
* Genetic disorder. * Known primary or secondary immunodeficiency . * Pregnancy or lactating
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| clock gene expression levels in intestinal mucosal samples and WBC peripheral blood. | 4 years | PCR amplification levels |
Countries
Israel
Outcome results
None listed