Stroke-like Migraine Attacks After Radiation Treatment (SMART) Syndrome Language Intervention

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03662295

Enrollment

Registered

2018-09-07

Start date

2018-09-03

Completion date

2019-11-13

Last updated

2021-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Migraine Disorders, Aphasia

Keywords

Cognitive Impairment

Brief summary

Stroke-like migraine attacks after radiation therapy-also known as SMART syndrome-constitute a rare condition typically characterized by headache, seizures, vision abnormalities, hemiparesis, and aphasia. The condition usually resolves within a few days or weeks of onset with no residual impairments. However, resolution in some cases extends over a period of months rather than weeks and may be incomplete. The purpose of this case report is to provide an in-depth description of the progression of changes in cognitive and language functioning for a person exhibiting SMART syndrome characterized by slow recovery.

Interventions

BEHAVIORALLanguage treatment

Individual speech-language therapy sessions totaling 1.5 to 2.5 hours five days per week. Intervention activities include performing oral and written confrontation and responsive naming, writing single words to dictation, reading single words and sentences aloud, and generating written and spoken picture descriptions.

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

19 Years to 65 Years

Inclusion criteria

* exhibit cognitive and language deficits secondary to SMART syndrome * be a former or current client of Quality Living, Inc., Omaha, Nebraska * be a native speaker of English

Exclusion criteria

Design outcomes

Primary

Measure	Time frame	Description
Standardized assessment	Change from baseline at 6 months	Aphasia Quotient of the Western Aphasia Battery - Revised

Secondary

Measure	Time frame	Description
Spoken picture description	Change from baseline at 6 weeks, 10 weeks, 14 weeks, 20 weeks, and 26 weeks	Spoken language sample elicited through a request to describe events depicted in a Norman Rockwell drawing.
Written picture description	Change from baseline at 6 weeks, 10 weeks, 14 weeks, 20 weeks, and 26 weeks	Written language sample elicited through a request to write about events depicted in a Norman Rockwell drawing.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026