Skip to content

Investigating the Structured Use of Ultrasound Scanning for Fetal Growth

Investigating the Structured Use of Ultrasound Scanning for Fetal Growth (Oxford Growth Restriction Identification Programme (OxGRIP)) on Risk Factors for and the Incidences of Adverse Maternal, Fetal and Neonatal Outcome

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03662178
Acronym
OxGRIP
Enrollment
56000
Registered
2018-09-07
Start date
2017-09-01
Completion date
2029-09-30
Last updated
2026-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fetal Death, Fetal Growth Restriction, Fetal Growth Retardation, Intrauterine Growth Restriction, Perinatal Death, Small for Gestational Age, Stillbirth

Brief summary

Fetal growth restriction during pregnancy represents one of the biggest risk factors for stillbirth (Gardosi et al, 2013), with 'about one in three term, normally formed antepartum stillbirths are related to abnormalities of fetal growth' (MBRRACE, 2015). Therefore, antenatal detection of growth restricted babies is vital in order to be able to monitor and decide the appropriate delivery timing. However, antenatal detection of SGA babies has been poor, varying greatly across trusts in England in those that calculate their rates (NHS England, 2016). Most trusts do not calculate their detection rates and rates are therefore unknown. It is estimated that routine NHS care detects only 1 in 4 growth restricted babies (Smith, 2015). Oxford University Hospitals NHS Foundation Trust, in partnership with the Oxford Academic Health Science Network (AHSN) has introduced a clinical care pathway (the Oxford Growth Restriction Pathway (OxGRIP)) designed to increase the rates of detection of these at risk babies. The pathway is intended to increase the identification of babies who are at risk of stillbirth, in order to try to prevent this outcome, whilst making best usage of resources, and restricting inequitable practice and unnecessary obstetric intervention. It has been developed with reference to a body of research, however, the individual parts of care provided have not been put together in a pathway in this manner before. Therefore it is important to examine whether the pathway meets its goals of improving outcomes for babies in a 'real world' setting. The principles of the pathway are 1. A universal routine scan at 36 weeks gestation. 2. Additional growth scans at 28 and 32 weeks gestation based on a simplified assessment of risk factors and universal uterine artery Doppler at 20 weeks gestation. 3. Assessment of further parameters other than estimated fetal weight associated with adverse perinatal outcome (eg growth velocity, umbilical artery Doppler and CPR). The clinical data routinely collected as a result of the introduction of the pathway offers a valuable and unique resource in identifying and analysing in the effects of the pathway on its intended outcomes and also in investigating and analysing other maternal, fetal and neonatal complications and outcomes, establishing normal / reference ranges for ultrasound values.

Detailed description

There is no requirement for patient participation in this study. All data collected and analysed is routinely collected clinical data.

Interventions

None listed

Sponsors

Oxford University Hospitals NHS Trust
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
OTHER

Eligibility

Sex/Gender
FEMALE
Age
16 Years to 60 Years
Healthy volunteers
Yes

Inclusion criteria

• All pregnant women receiving antenatal care at the Oxford University Hospitals NHS Foundation Trust (OUHFT) from January 2013 to 31st December 2019 with no

Design outcomes

Primary

MeasureTime frameDescription
Impact of OxGRIP on Perinatal mortality according to gestation4 yrsMortality (stillbirth and neonatal death per 1000 pregnancies) in the period after birth) assessed in 2 years before the programme and compared with the 2 years after the programme started. Assessed for all pregnancies and for those reaching 35 weeks' gestation

Secondary

MeasureTime frameDescription
Impact of the OxGRIP Pathway on service: number of scans6 yrsNumber of Ultrasound Scans (\>24 weeks gestation) performed per pregnancy
Impact of the OxGRIP Pathway on service - Consultant time6 yrsNumber of Consultant appointments
Impact of the OxGRIP Pathway on service - intrapartum interventions6 yrsProportion of all birth delivered as emergency and elective cesarean sections and instrumental deliveries
Risk Factors for adverse outcomes - ultrasound head circumference4 yrsRoutinely collected ultrasound fetal measurements - Head Circumference. Physiological parameter
Risk Factors for adverse outcomes - ultrasound abdomen circumference4 yrsRoutinely collected ultrasound fetal measurements - Abdominal Circumference.Physiological parameter
Risk Factors for adverse outcomes - ultrasound femur length4 yrsRoutinely collected ultrasound fetal measurements - Femur Length. Physiological parameter
Risk Factors for adverse outcomes - ultrasound presentation4 yrsFetal presentation at last scan before birth. Physiological parameter
Risk Factors for adverse outcomes - Doppler ultrasound4 yrsUterine/umbilical artery/ middle cerebral artery Doppler values. Physiological parameter
Clinical outcomes during pregnancy and postnatal/neonatal period: hypertension4 yrsDiagnosis of pre eclampsia and related complications. Physiological parameter
Clinical outcomes during pregnancy and postnatal/neonatal period: diabetes4 yrsDiagnosis of Gestational Diabetes. Physiological parameter
Clinical outcomes during pregnancy and postnatal/neonatal period: mode of birth4 yrsMode of Delivery
Clinical outcomes during pregnancy and postnatal/neonatal period: preterm birth4 yrsNumber of preterm births by gestation per 1000 pregnancies
Clinical outcomes during pregnancy and postnatal/neonatal period: stillbirth4 yrsAntenatal fetal loss rate per 1000 pregnancies
Clinical outcomes during pregnancy and postnatal/neonatal period: intrapartum stillbirth4 yrsIntrapartum fetal loss rate per 1000 pregnancies
Clinical outcomes during pregnancy and postnatal/neonatal period: neonatal death4 yrsNeonatal death \<30 days of age: rate per 1000 livebirths
Clinical outcomes during pregnancy and postnatal/neonatal period: infant4 yrsNeonatal/infant death \>30 days of age \<1year of age: per 1000 live births
Clinical outcomes during pregnancy and postnatal/neonatal period: neonatal admission4 yrsAdverse neonatal outcome - planned/unplanned admission to NICU: rate per 1000 pregnancies
Clinical outcomes during pregnancy and postnatal/neonatal period: HIE4 yrsAdverse neonatal outcome - diagnosis of HIE rate per 1000 pregnancies
Clinical outcomes during pregnancy and postnatal/neonatal period: cord gas4 yrsCord Blood Gases outside normal range (umbilical cord arterial pH at birth \<7.00 and \<7.05)
Clinical outcomes during pregnancy and postnatal/neonatal period: Apgar4 yrsApgar score at birth (continuous variable and rate of \<7 at 5 mins)
Clinical outcomes during pregnancy and postnatal/neonatal period: size4 yrsSmall for Gestational Age birthweight - by Hadlock and Intergrowth centiles. Physiological parameter
Normal ranges of antenatal ultrasound markers.4 yrsDevelopment of normal range of routinely collected ultrasound measurements. Physiological parameter
Normal ranges of intrapartum markers.4 yrsCardiotocograph results ( Dawes Redman Criteria). Physiological parameter

Countries

United Kingdom

Contacts

CONTACTLawrence Impey
lawrence.impey@ouh.nhs.uk01865 851165
CONTACTChristina Aye
christina.aye@ouh.nhs.uk
STUDY_DIRECTORLawrence Impey, FRCOG

Oxford University Hospitals NHS Trust

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026