Effect of Domperidone on Completion Rate of Vedio Capsule Endoscopy

Effect of Domperidone on Completion Rate of Vedio Capsule Endoscopy: a Prospective Randomized Controlled Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03662113

Enrollment

200

Registered

2018-09-07

Start date

2017-11-01

Completion date

2018-11-01

Last updated

2018-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Capsule Endoscopy, Pediatric Disorder

Keywords

domperidone

Brief summary

Video capsule endoscopy (VCE) has become an established technique to investigate the presence of small bowel pathology. But the limited battery life of capsules can lead to incomplete small bowel visualization. There is a rationale to use prokinetic agents prior to VCE reduce the chances of an incomplete small bowel examination via decrease gastric transit time (GTT). Investigators are aimed to prospectively compare the completion rate of VCE in pediatric patients receiving prokinetic with those receiving no prokinetic.

Detailed description

Eligible children were randomly divided into two groups: domperidone prior to VCE and water prior to VCE. The primary outcome measure was the completion rate. Secondary outcome measures included the GTT and SBTT.

Interventions

DRUGDomperidone

5ml Domperidone prior to VCE

DIETARY_SUPPLEMENTwater

5ml water prior to VCE

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

HEALTH_SERVICES_RESEARCH

Masking

DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

3 Years to 18 Years

Healthy volunteers

Inclusion criteria

* Indications of capsule endoscopy; * Informed consent form obtained.

Exclusion criteria

* Contraindication of capsule endoscopy; * Domperidone allergy; * Unwilling to participate.

Design outcomes

Primary

Measure	Time frame	Description
Completion rate of capsule endoscopy	assessed through study completion, an average of 1 year	CE was considered complete when the cecum was reached within recording time.

Secondary

Measure	Time frame	Description
Gastric transit time (GTT)	assessed through study completion, an average of 1 year	The GTT was defined as the time, in minutes, from the first image of the stomach until the first image of the duodenum.
small bowel transit time (SBTT)	assessed through study completion, an average of 1 year	The SBTT was defined as the passage time, in minutes, from the first image of the duodenum until the first image of the cecum.

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 24, 2026