Septic Shock
Conditions
Brief summary
Fluid challenge is often carried out in septic shock patients. Its responsiveness usually requires invasive monitoring. The pulmonary artery catheter(PAC) is the most effective means of monitoring.To use non-invasive methods is very tempting. Investigators hypothesize that venous-to-arterial carbon dioxide difference,venous-to-arterial carbon oxygen difference, central venous-arterial carbon dioxide to arterial-venous oxygen content ratio and Central Venous SO2 variations provides feasible estimation on fluid responsiveness in septic shock patients.
Interventions
OTHERfluid chanllenge
A bag of 500ml of normal saline is infused within 15 minutes using a bag pressurized to 300 mmHg.
Sponsors
Chengdu Fifth People's Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
A bag of 500ml of normal saline is infused within 15 minutes using a bag pressurized to 300 mmHg. All other treatments, including maintenance fluids, dose of vasoactive agents and ventilator settings, remain unchanged during the study period.
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* more than 18 years old; less than 75 years old ICU patients * Septic shock * Monitored with pulmonary artery catheter (Swan-Ganz catheter) * The decision of fluid challenge made by the treating physician
Exclusion criteria
* Evidence of fluid overload * Pregnancy * Recently participated in other studies * Severe heart failure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cardiac index change | Immediately after fluid challenge | Fluid responsiveness: increase in CI of at least 10% after fluid challenge ;Fluid nonresponsiveness:no increase or increase in CI less than 10%. |
Countries
China
Contacts
Primary Contactxiang xiang, MD
Outcome results
None listed