Autonomic Neuropathy, Burns, Chemotherapy Effect, Headache, Heart Failure, Hypertension, Intracranial Hemorrhages, Migraine, Multiple Sclerosis, Pain, Radiation Injuries, Scleritis, Stroke, TIA, Uveitis, Vascular Ischemia
Conditions
Keywords
perfusion, inflammatory, ischemia, lesions, neuropathy, burns, cancer, stroke
Brief summary
The purpose of this project is to quantify normal and abnormal skin blood flow regionally in different areas of the body(face, extremities, over burns and wounds) at baseline and over time in response to treatment or environmental changes, such as temperature, light and pressure.
Detailed description
Laser speckle skin blood flow (LSFG-SKIN) will be recorded in normal subjects and in patients with disorders affecting skin capillary perfusion, which may include cardiovascular disorders, dermatologic disorders, skin wounds, ocular disorders, psychiatric disorders, and neurologic disorders.
Interventions
DEVICElaser speckle flowgraphy
blood flow state of the skin as real time two dimensional image
Sponsors
Randy Kardon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
Controls ●Healthy normal control subjects ages 18-90 Cardiology Subjects * Ages 18-90 * History of dysrhythmia, heart failure, cardiac ischemia, hypertension, peripheral vascular disease Dermatology Subjects * Ages 18-90 * History of inflammatory and cancerous lesions Endocrine Subjects * Ages 18-90 * History of diabetes, thyroid disease Neurology Subjects * Ages 18-90 * History of dementia, headaches, Parkinson's, light sensitivity, stroke, TIA, multiple sclerosis Psychiatry Subjects * Ages 18-90 * History of bipolar, schizophrenia, anxiety, depression Surgery Subjects * Ages 18-90 * History of skin wounds(trauma, chemotherapy, radiation), thermal burns, or plastic and reconstructive surgical procedures. Ophthalmology Subjects * Ages 18-90 * History of ocular disorders caused by hypo perfusion or inflammatory disorders
Exclusion criteria
Controls * Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay. * Angle closure glaucoma Cardiology Subjects * Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay. * Angle closure glaucoma 3\. Dermatology Subjects * Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay. * Angle closure glaucoma Endocrine Subjects * Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay. * Angle closure glaucoma Neurology Subjects * Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay. * Angle closure glaucoma Psychiatry Subjects * Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay. * Angle closure glaucoma Surgery Subjects * Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay. * Angle closure glaucoma Ophthalmology Subjects * Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay. * Angle closure glaucoma
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Imaging Blood Flow | One visit | Imaging blood flow in the tissue is of major importance in the clinical environment |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Clinic Subjects cardiology subjects, dermatology subjects, endocrine subjects, neurology subjects, psychiatry subjects, surgery subjects, ophthalmology subjects.
laser speckle flowgraphy: blood flow state of the skin as real time two dimensional image | 1 |
| Total | 1 |
Baseline characteristics
| Characteristic | Clinic Subjects |
|---|---|
| Age, Continuous | 55 years |
| Race (NIH/OMB) American Indian or Alaska Native | 0 Participants |
| Race (NIH/OMB) Asian | 0 Participants |
| Race (NIH/OMB) Black or African American | 0 Participants |
| Race (NIH/OMB) More than one race | 0 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 0 Participants |
| Race (NIH/OMB) White | 1 Participants |
| Sex: Female, Male Female | 1 Participants |
| Sex: Female, Male Male | 0 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | 0 / 1 |
| other Total, other adverse events | 0 / 1 |
| serious Total, serious adverse events | 0 / 1 |
Outcome results
Primary
Imaging Blood Flow
Imaging blood flow in the tissue is of major importance in the clinical environment
Time frame: One visit
Population: One subject tested before device had to be returned due to company going out of business. Data was not measurable and no repeat testing was possible as device was returned.