Iron Bioavailability of High Surface Area Ferric Phosphate

Iron Bioavailability of High Surface Area Ferric Phosphate in Thai Women

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03660462

Acronym

HiFe

Enrollment

Registered

2018-09-06

Start date

2018-11-21

Completion date

2019-07-19

Last updated

2021-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Iron-deficiency

Brief summary

The primary objective of this study is to compare iron absorption of high surface area ferric phosphate with that of ferrous sulfate and bulk ferric phosphate in a rice-based meal in non-pregnant women.

Interventions

DIETARY_SUPPLEMENTFeSO4 fortified rice test meal

Rice test meal extrinsically labeled with 2 mg ferrous sulfate (58FeSO4)

DIETARY_SUPPLEMENTFePO4 fortified rice test meal

Rice test meal extrinsically labeled with 2 mg ferric phosphate (58FePO4)

DIETARY_SUPPLEMENTHiFePO4 1 fortified rice test meal

Rice test meal extrinsically labeled with 2 mg high surface ferric phosphate 1 (57FePO4)

DIETARY_SUPPLEMENTHiFePO4 2 fortified rice test meal

Rice test meal extrinsically labeled with 2 mg high surface ferric phosphate 2 (57FePO4)

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 49 Years

Healthy volunteers

Yes

Inclusion criteria

* Women of reproductive age (18 to 49 years) in Thailand * BMI \< 23 kg/m2 * Body weight \< 65 kg * Mildly anaemic to normocythemic (Hb 80-110 g/L) * Ferritin \< 25 µg/L * Not pregnant (confirmed by pregnancy test stripe) or lactating * No inflammation (CRP \< 5 mg/L) * Having provided written informed consent

Exclusion criteria

* Haemoglobinopathies (except heterozygosity for haemoglobin E and alpha-thalassemia 1) * Coeliac disease or other chronic diseases of malabsorption that could influence iron absorption or metabolism * Blood donation or significant blood loss due to surgery or accident \< 4 months before start of the study * Consumption of vitamin or mineral supplements 2 weeks before start of the study * Regular use of medication (except oral contraceptives), that influences iron absorption * Chronic inflammatory disease * Smoking

Design outcomes

Primary

Measure	Time frame	Description
Fractional iron absorption	Measured 14 days after consumption of the 4 different types of iron vehicles (Days 16 and 31)	Iron absorption will be determined by measurement of the isotopic ratio change from the 4 different types of iron vehicles (FeSO4 fortified rice test meal, FePO4 fortified rice test meal, HiFePO4 1 fortified rice test meal, HiFePO4 2 fortified rice test meal).

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026