Impact of OFA During LPV on Postoperative Oxygen Saturation

Observational Study Evaluating the Impact of Opioid Free Anesthesia During Lung Protective Ventilation on Postoperative Oxygen Saturation.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03660306

Enrollment

Registered

2018-09-06

Start date

2018-08-01

Completion date

2019-11-05

Last updated

2019-12-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Decreased Lung Compliance, Oxygen Requirement

Brief summary

Opioids used intra operative increase the amount of opioids needed post operative to control post operative pain. if opioids are given post operative, we assume that more atelectasis and hypoxia takes place even after lung protective ventilation. These postoperative lower oxygen saturations will require giving more frequent oxygen therapy.

Detailed description

This is an observational study where the attending anesthesiologist decides to use opioid free or opioid general anesthesia based on his/her expertise. Every patient gets a lung protective ventilation and emergence from anesthesia using the principles set forward in the consensus meeting by Young C BJA 2019. A lung recruitment followed by high PEEP is given when lung compliance decreases below 40 ML/cmH20. The lowest oxygen saturation without adding oxygen therapy is noted post extubation at moment of admission in PACU, after having given an opioid as analgesic and at moment of discharge from PACU.. If post operative satuation drops below 94% oxygen therapy is given and noted.

Interventions

PROCEDUREopioid anesthesia

opioid anesthesia means using sufentanil during surgery

PROCEDUREopioid free anesthesia

opioid free anesthesia means giving no opioids during surgery

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* major surgery where intubation with mechanical ventilation is required * obese patients with BMI \> 35

Exclusion criteria

* spontaneous breathing during procedure * allergic to any of the drugs used in both groups * severe liver, renal, cardiac or pulmonary disease

Design outcomes

Primary

Measure	Time frame	Description
oxygen requirement post operative to maintain saturation above 94%	first 24 hours post operative	oxygen saturation

Secondary

Measure	Time frame	Description
postoperative pain	first 24 hours post operative	postoperative pain measured by VAS score
postoperative opioid consumption	first 24 hours post operative	postoperative opioid consumption measured by morphine equivalents

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026