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Luftibus in the School: a Study on the Respiratory Health of Schoolchildren.

Luftibus in the School: a Population-based Study of Respiratory Symptoms, Lung Function and Air Pollution.

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03659838
Acronym
LUIS
Enrollment
3500
Registered
2018-09-06
Start date
2013-11-28
Completion date
2016-12-15
Last updated
2018-09-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Disease

Keywords

Asthma, Wheeze, Cough, Snoring, Bronchial obstruction, Air pollution

Brief summary

This study assessed the respiratory health of schoolchildren from the canton of Zurich by combining self-reported information on respiratory symptoms with lung function test results and air pollution measurements. Luftibus in the school (LUIS) is a population-based study conducted in the canton of Zurich, Switzerland. Between the years 2013 and 2016 a bus with equipment for lung function testing and air pollution measurement visited numerous schools across the canton Zurich. The parents of the schoolchildren filled in a questionnaire with validated questions on upper and lower respiratory symptoms, trigger factors, diagnosis, treatment of respiratory symptoms, health behavior and environmental factors. The children were interviewed using a shorter questionnaire. Fieldworkers measured lung function (spirometry and double tracer gas single-breath washout) and an airway inflammation test (fractional exhaled nitric oxide) in the bus. The recruited population included 3500 schoolchildren aged 6 to 16 years from the canton of Zurich. Respiratory symptoms and their influence on physical activity and sleep have a strong impact on children's quality of life and school performance. The results of this study will provide new insights on schoolchildren's respiratory health that may help to establish new recommendations and influence policy makers' decisions.

Detailed description

Background: Few population-based studies have recently investigated the epidemiology of childhood respiratory symptoms in Switzerland. Objectives: The Luftibus in the school study was setup to assess the respiratory health of schoolchildren from the canton of Zurich and to investigate relationships between respiratory symptoms, lung function and air pollution. Methods: Recruitment and participation: All schools in the canton of Zürich were invited to participate in the LUIS study. Those schools interested in participating were approached. The eligible study population were children aged 6 to 16 years with parental consent from the schools that agreed to participate. Prior to each school visit, parents received a letter with information about the project, an informed consent form and a questionnaire. During the school visit, trained field workers performed lung function tests in children at the school, interviewed the children using a short questionnaire and collected the parental questionnaires. A subsample of the schools was visited again one year after the first visit in order to collect follow-up information, using the same procedure and gathering the same measurements. Information collected: \- Parental questionnaire: Frequency, duration, severity, triggers of upper and lower respiratory symptoms, previous doctor diagnosis of asthma, use of medication, health behaviors, environmental factors, household characteristics and family history. \- Children's questionnaire: Respiratory symptoms, asthma diagnosis, medication and smoking. \- Anthropometric data: Height and weight were measured by fieldworkers in the schools in a standardized way. \- Complementary tests: Spirometry, fractional exhaled nitric oxide (FeNO) and double tracer gas single-breath washout (SBW) were performed in the school by trained fieldworkers according to ATS criteria. \- Air pollution measurements: Air pollution detectors placed on the roof of the bus measured nitrogen dioxide (NO2), inhalable particles of 10 micrometers or less in diameter (PM10) and ozone concentration at the school site. Study database: The study questionnaire database was created using Epidata, which allows data entry and data extraction in CVS format. Funding: Lung League of Zurich

Interventions

None listed

Sponsors

University of Bern
CollaboratorOTHER
University Children's Hospital, Zurich
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
6 Years to 16 Years
Healthy volunteers
Yes

Inclusion criteria

* Schoolchildren living in the canton of Zürich * Age range 6 to 16 years * Parental consent to participate

Design outcomes

Primary

MeasureTime frameDescription
Airway inflammationAt baselineAirway inflammation measured by levels of fractional concentration of exhaled nitric oxide.
Parent-reported respiratory symptomsAt baselinePrevalence of upper and lower respiratory tract symptoms including wheeze, cough, rhinitis and snoring, reported using parent questionnaires.
Self-reported respiratory symptomsAt baselinePrevalence of upper and lower respiratory tract symptoms including wheeze, cough, rhinitis and snoring, reported using participant questionnaires.
Lung function measurements: Spirometry, forced expiratory volume in 1 second z-scoresAt baselineForced expiratory volume in 1 second (FEV1) z-scores calculated based on Global Lung Function Initiative (GLI) reference values.
Lung function measurements: Spirometry, forced vital capacity z-scoresAt baselineForced vital capacity (FVC) z-scores calculated based on Global Lung Function Initiative (GLI) reference values.
Lung function measurements: Single-breath washoutAt baselineSlope from the tidal (alveolar) phase III (SIII) from double-tracer gas single-breath washout test curves.

Secondary

MeasureTime frameDescription
Parent-reported respiratory symptomsOne year after baselinePrevalence of upper and lower respiratory tract symptoms including wheeze, cough, rhinitis and snoring, reported using parent questionnaires.
Self-reported respiratory symptomsOne year after baselinePrevalence of upper and lower respiratory tract symptoms including wheeze, cough, rhinitis and snoring, reported using participant questionnaires.
Lung function measurements: Spirometry, forced expiratory volume in 1 second z-scoresOne year after baselineForced expiratory volume in 1 second (FEV1) z-scores calculated based on Global Lung Function Initiative (GLI) reference values.
Lung function measurements: Spirometry, forced vital capacity z-scoresOne year after baselineForced vital capacity (FVC) z-scores calculated based on Global Lung Function Initiative (GLI) reference values.
Lung function measurements: Single-breath washoutOne year after baselineSlope from the tidal (alveolar) phase III (SIII) from double-tracer gas single-breath washout test curves.
Airway inflammationOne year after baselineAirway inflammation measured by levels of fractional concentration of exhaled nitric oxide.

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 10, 2026