Dysbiosis
Conditions
Brief summary
The specific aim for this project will be to investigate a cranberry beverage as a means to restore balance in terms of the relative proportions of the various bacteria that inhabit the large intestine.
Interventions
OTHERCranberry beverage
During the intervention period, research participants will consume a cranberry beverage daily.
OTHERPlacebo beverage
During the intervention period, research participants will consume a placebo beverage daily.
Sponsors
Iowa State University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI 27-35 kg/m2 * High waist circumference (men \>102 cm and women \>88 cm)
Exclusion criteria
* Cigarette smoking * Regular intensive exercise * Pregnancy or lactation * Chronic diarrhea, constipation, or other gastrointestinal complaint * Diabetes mellitus, autoimmune disease, or other chronic disease known to alter the gut microbiota * Use of medications that affect inflammation or the gut microbiota * Use of prebiotics, probiotics, synbiotics, vitamins, or other dietary supplements known to affect the gut microbiota * Aversion to cranberries * Food allergies * Lactose intolerance * Vegetarianism
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fecal microbial community composition and structure | Changes in the fecal microbiota will be measured after a 20-day intervention period | We will investigate if specific bacterial taxa are stimulated by daily consumption of a cranberry beverage. |
Countries
United States
Outcome results
None listed