Insulin Resistance
Conditions
Keywords
Insulin resistance, Diabetes mellitus, Carbohydrate
Brief summary
Insulin resistance is a positive protective reaction against surgery .this resistance has some negative consequences for patient health. It is associated with infectious complications. At the same time, Postoperative insulin resistance has been shown to correlate with the length of postoperative stay in hospital. Recently several clinical studies have shown that a carbohydrate-rich drink given 2 h before surgery diminishes postoperative insulin resistance in patient. The aim of our study is to investigate the influence on insulin resistance in patient with diabetes.
Detailed description
Insulin resistance is a positive protective reaction against surgery . As a response to surgery, activation of neuroendocrine and inflammation systems occurs as a protective reaction. However, this resistance has some negative consequences for patient health. It is associated with infectious complications. At the same time, Postoperative insulin resistance has been shown to correlate with the length of postoperative stay in hospital. Recently several clinical studies have shown that a carbohydrate-rich drink given 2 h before surgery diminishes postoperative insulin resistance in patient. The aim of our study is to investigate the influence on insulin resistance in patient with diabetes.
Interventions
DIETARY_SUPPLEMENTPreoperative Oral Carbohydrate Drink
Patients in Oral carbohydrate group consumed 400 ml Preoperative Oral Carbohydrate Drink Nutricia preOp® (12.5% carbohydrates, 0.5kcal/ml, 240 mOsm, pH 4.9, Nutricia Zoetermeer, the Netherlands) 3 hours prior to induction of anesthesia and finished the ingestion within 20 minutes.
Sponsors
The Second Affiliated Hospital of Dalian Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* patients underwent elective open colorectal resection for colorectal carcinoma and electric orthopedic surgery
Exclusion criteria
* Weight loss greater than 10 per cent during the previous 6 months * Renal insufficiency (creatinine, \> 3 mg/dl; hemodialysis) * Hepatic insufficiency (Child-Pugh class, ≥ B) * Gastro-oesophageal reflux disease * Gastrointestinal obstruction or conditions (including pharmacological treatment) known to affect gastric emptying rate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| VAS | 1 day (preoperative period) | Preoperative general well-beings before assessed with the visual analogue scale (VAS). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| HOMA | perioperative period) | Preoperative insulin resistance before and immediately after the surgery assessed with the homeostasis model assessment (HOMA) |
Countries
China
Contacts
Primary Contactyang z Xiao, MD,PhD
Outcome results
None listed