Bronchopulmonary Dysplasia
Conditions
Brief summary
The investigators are wanting to learn more about early development of the lungs and to help them better understand prematurity and the development of a breathing disorder call BPD (Bronchopulmonary Dysplasia)
Detailed description
This is an observational case study involving up to three MRI visits. The first MRI will be complete after the infant's clinical initial evaluation. The second image will be obtained approximately 1 month later and the third MRI will be complete prior to discharge. Infants will be imaged at various ages, based up their initial evaluation. The investigators will collect urine and obtain clinically collected remnant blood around time of MRI, tracheal/endotracheal aspirate at time of the MRI when available and BAL samples as clinically available. MRI findings will be correlated with laboratory findings and outcomes from the medical record, and a research database will be built for the data. The investigators will also obtain a one-time MRI visit in non-BPD NICU patients to acquire data related to normal vasculature and pulmonary alveolar development. Sub-study 1: Inpatient polysomnography Patients with the same inclusion/exclusion criteria as reported below will be approached for a brief inpatient polysomnogram. The population will include patients with and without BPD. The polysomnography (PSG) will be performed in the NICU within 1 week from the MRI that is obtained prior to discharge.
Interventions
DIAGNOSTIC_TESTNICU MRI
MRI device that is not FDA approved.
DIAGNOSTIC_TESTPolysomnography
Polysomnography to better determine obstruction index in the airway.
Sponsors
Children's Hospital Medical Center, Cincinnati
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 4 Months
Healthy volunteers
Yes
Inclusion criteria
* any term age NICU patient
Exclusion criteria
* \- ECMO, * Evidence of congenital diseases that may affect lung development, such as congenital diaphragmatic hernia, * Suspected muscular dystrophy or neurologic disorder that may affect lung development. * Significant genetic or chromosomal abnormalities that may affect lung development * Evidence of any respiratory infection at the time of imaging (imaging may be rescheduled for a common viral infection such as a cold). * Standard MRI
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Anatomic phenotypes using MRI | baseline | Investigate parenchymal and vascular structures, regional cardiopulmonary function, and dynamic airway collapse in BPD infants during quiet unsedated breathing. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Polysomnography | within a week of baseline MRI | Determine the correlation between upper airway MRI and the obstruction index in the polysomnography. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Change in the anatomic phenotype using MRI | 1 month post baseline and discharge from NICU | Compare the parenchymal reader scoring, cardiac analysis, and airway scoring over the span of the BPD infant's time in the NICU. |
Countries
United States
Contacts
Primary ContactMegan Schmitt
Backup ContactAshley Bordon, MS
Outcome results
None listed