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Effects of PEP on IC During IT in Patients With COPD

Effects of Positive Expiratory Pressure on Inspiratory Capacity and Dyspnea in Patients With COPD During Exercise

Status
Terminated
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03657082
Enrollment
1
Registered
2018-09-04
Start date
2018-09-15
Completion date
2021-12-30
Last updated
2024-05-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstructive Pulmonary Disease

Brief summary

This study will investigate the effects of positive expiratory pressure (PEP) on hyperinflation in patients with chronic obstructive pulmonary disease (COPD). Inspiratory capacity (IC) is the primary outcome

Detailed description

This is a cross-over intervention assessing the effect of PEP on IC and dyspnea in patients with COPD performing an interval training (IT) session. IC will be measured before, during and immediately after the IT session. Each participant will receive perform IT sessions including either the use of a PEP of 10 cmH2O or a PEP of 1 cmH2O. The effects on IC and dyspnea on both PEP levels will be assessed.

Interventions

DEVICEPEP-10

Bottle PEP with a water level of 10 cmH2O

DEVICEPEP-1

Bottle PEP with a water level of 1 cmH2O

Sponsors

Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
45 Years to 95 Years
Healthy volunteers
No

Inclusion criteria

* Stable COPD since 1 month at least * Able to understand the instructions

Exclusion criteria

* COPD with a forced expiratory volume at one second \> 80% of predicted values * In exacerbation * Orthopedic of neurological condition likely to interfere with the experimentation * Contraindication to perform exercise

Design outcomes

Primary

MeasureTime frameDescription
Change in inspiratory capacity20 minutesEvolution of inspiratory capacity while performing the interval training session

Secondary

MeasureTime frameDescription
Change in Borg scale20 minutesEvolution of dyspnea while performing the interval training session

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026