Pleural Effusion
Conditions
Brief summary
The purpose of this study is to determine whether adding new methods of data visualization to routine clinical care will improve (i) surgical planning and (ii) surgical outcomes in patients with kidney and prostate tumors.
Detailed description
This early phase I trial studies how well indwelling pleural catheters with doxycycline work compared to indwelling pleural catheters alone in treating participants with malignant pleural effusions. These types of catheters are commonly used to treat pleural effusions (build-up of fluid in the lungs). Doxycycline is an antibiotic that is also used to treat pleural effusions. It is not yet known whether giving doxycycline with indwelling pleural catheters works better than indwelling pleural catheters alone in treating participants with cancerous pleural effusions.
Interventions
DIAGNOSTIC_TESTRoutine CT
CAT (Computerized Axial Tomography) scan, is a noninvasive X-ray test that is used to diagnose a variety of medical conditions.
DIAGNOSTIC_TESTRoutine imaging CT with a 3D printed model
CAT (Computerized Axial Tomography) scan, is a noninvasive X-ray test that is used to diagnose a variety of medical conditions + 3D Printed Model
DIAGNOSTIC_TESTRoutine imaging MRI with a 3D printed model
will measure post-operative lesion volume as visualized on the post-operative MRI + 3D Printed Model
DIAGNOSTIC_TESTRoutine MRI
will measure post-operative lesion volume as visualized on the post-operative MRI
DIAGNOSTIC_TESTRoutine imaging CT with a VR model
CAT (Computerized Axial Tomography) scan, is a noninvasive X-ray test that is used to diagnose a variety of medical conditions + VR Model
DIAGNOSTIC_TESTRoutine imaging MRI with a VR model
will measure post-operative lesion volume as visualized on the post-operative MRI + VR Model
Sponsors
NYU Langone Health
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Outpatients with MPE undergoing IPC placement * Sufficient mental capacity to provide informed consent and answer Short-Form Six-Dimension health index (SF-6D) and Borg score questions
Exclusion criteria
* Patients undergoing pleurodesis for benign disease (e.g., spontaneous pneumothorax) * Inability or unwillingness to give informed consent * Inability to perform phone call and clinical follow-up at MD Anderson Cancer Center (MDACC) * Pregnancy * Previous intrapleural therapy for MPE on the same side * Eastern Cooperative Oncology Group (ECOG) of 4 and life expectancy ≤ 2 weeks * Doxycycline allergy * Extensive loculations or hydropneumothorax or other contraindication to pleurodesis * Chylous effusions associated with malignant disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measure of Operative Time | Post Surgery | measure of the amount of time it takes surgeon to remove tumor |
Countries
United States
Outcome results
None listed