Does the Addition of Hydrogen Peroxide to Chlorhexidine Skin Prep to Treat P. Acnes in the Shoulder

Does the Addition of Hydrogen Peroxide to Chlorhexidine Preoperative Skin Preparation Reduce the Rate of Propionibacterium Acnes Positive Culture in the Shoulder

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03656588

Enrollment

100

Registered

2018-09-04

Start date

2018-04-16

Completion date

2019-02-28

Last updated

2018-09-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Propionibacterium Infection

Brief summary

This is a prospective, randomized controlled trial to evaluate the ability of hydrogen peroxide preparation in addition to chlorhexidine to decrease the colonization of Propionibacterium acnes(a bacteria commonly found in the dermis of the skin surrounding the shoulder in order to decrease postoperative joint infection.

Interventions

DRUGa. Standard iodine scrub, 3% hydrogen peroxide prep, follow by ChloraPrep (2% chlorhexidine gluconate and 70% isopropyl alcohol

a. Standard iodine scrub, 3% hydrogen peroxide prep, follow by ChloraPrep (2% chlorhexidine gluconate and 70% isopropyl alcohol

DRUGIodine scrub and ChloraPrep alone

Iodine scrub and ChloraPrep alone

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1\. All male patients (\>18) undergoing shoulder arthroscopy

Exclusion criteria

1. Female patients 2. Patients with active acne 3. Patients who have taken antibiotics within a month of their surgery 4. Subjects allergic to any of the following agents: o Benzoyl peroxide 5. Subjects with psoriatic/eczematous lesions on the shoulder girdle.

Design outcomes

Primary

Measure	Time frame	Description
colonization of p.acnes in the dermis of the shoulder	14 days in culture	number of colony forming units grown in bacterial culture

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026