Arteriovenous Malformations
Conditions
Keywords
Uterine AVM
Brief summary
Uterine arteriovenous malformations (UAVM) are short circuits between systemic arterial and venous networks within the uterus. They are congenital or acquired (in the course of an endo-uterine gesture such as curettage or interventions such as caesareans or myomectomies). They can be manifested by severe metrorrhagia that can go as far as to put the patient's vital prognosis at risk. There are no recommendations for the management of UAVM since this pathology is rare and therefore series are performed with few cases. If some of these UAVM disappear spontaneously after a therapeutic abstention, when the clinical context allows it, in case of symptomatic UAVM, a selective embolization with arteriography is often carried out to postpone the hysterectomy of hemostasis. There are also more marginal management options such as Gonadotropin-Releasing Hormone agonists, methotrexate or curettage that are decided on a case by case basis depending on the symptoms and protocols of each medical team. Regarding subsequent fertility and pregnancy outcomes after conservative treatment, the number of studies is even lower.
Interventions
OTHERTelephone interview
Patients are contacted by telephone to know the history of the disease since the diagnosis of UAVM and the impact of management on fertility. All medical data related to the care and necessary for the study are collected from the medical file the participation of the patients is limited to a telephone interview.
Sponsors
Rennes University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Major patient * Diagnosis of UAVM, symptomatic or not, between January 1st, 2000 and March 30th, 2017 confirmed by imagery performed at the Rennes University Hospital * Not against her participation in research
Exclusion criteria
* Minor patient at the time of diagnosis * congenital UAVM * Uterine malformation * Patient under legal protection (guardianship, curatorship, safeguard of justice).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of fertility | At the time of inclusion | The telephone interview seeks to assess fertility for all patients diagnosed with symptomatic or non-symptomatic UAVM regardless of initial management. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pregnancy outcomes after UAVM | At the time of inclusion | The telephone interview allows to evaluate pregnancy outcomes after diagnosis of UAVM regardless of initial management, in terms of live birth (full term or preterm birth), stillbirth, spontaneous abortion, and induced abortion. |
| Term of delivery after UAVM | At the time of inclusion | The telephone interview allows to evaluate the term of delivery after diagnosis of UAVM regardless of initial management |
| Side effects of treatments for UAVM | At the time of inclusion | The telephone interview allows to inventory the side effects of treatments |
| Complications of treatments for UAVM | At the time of inclusion | The telephone interview allows to evaluate the complications of treatments |
Countries
France
Outcome results
None listed