Cystic Fibrosis
Conditions
Keywords
Multiple breath washout, Electrical impedance tomography, Lung clearance index, Chest physiotherapy, Autogenic drainage, Cystic fibrosis
Brief summary
This study will investigate the effects of a chest physiotherapy manual technique (autogenic drainage) on ventilation inhomogeneity in patients with cystic fibrosis. Lung clearance index (LCI) is the primary outcome
Detailed description
This is a cross-over intervention assessing the effect of autogenic drainage on ventilation inhomogeneity in patients with cystic fibrosis. Electrical impedance tomography and multiple breath nitrogen washout will be performed before, immediatly after and 2h post intervention. Each participant will receive either aerosoltherapy alone or in combination with chest physiotherapy on 2 consecutive days.
Interventions
OTHERAutogenic drainage
Autogenic drainage is an airway clearance technique that attempts to obtain the optimal airflow to evacuate the secretions. This technique uses modulation of inspiratory and expiratory airflow at different breathing level within the vital capacity.
DRUGAerosoltherapy
Aerosolized drugs are individualized for each participants, in line with current standardized practice in our hospital. Those drugs will not be modified for the purpose of this study.
Sponsors
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Participants receive one of two interventions during the first day, and receive the alternative intervention the following day. Interventions are : aerosoltherapy + autogenic drainage or aerosoltherapy alone
Eligibility
Sex/Gender
ALL
Age
6 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Cystic fibrosis diagnosis * FEV1 \> 40% * Able to sustain 30min of chest physiotherapy
Exclusion criteria
* Presence of Burkoldheria cepacia or non tuberculous mycobacteria * Orthopedic, neuromuscular or cardiac disorder likely to impact respiratory system * Need for supplemental oxygen * Cardiac pacemaker or internal cardiac defibrillator
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Lung Clearance Index | Up to 2 weeks | LCI will be measured before, immediately after and 2h after the experimental or control conditions as well as before and after an hospitalization. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Impedance variation | Up to 1 hour | Impedance change in different lung zones |
Countries
Belgium
Contacts
Primary ContactWilliam Poncin, PT, PhD
Backup ContactGregory Reychler, PT, PhD
Outcome results
None listed