Medication Overuse Headache
Conditions
Keywords
melatonin, medication Overuse Headache, migraine, Neuropsychology
Brief summary
Medication overuse headache (MOH) is a disabling and costly disorder which is characterized by chronic headache and overuse of different headache medications. Patients with MOH are more likely to coexist with affective disorders such as anxiety and depression, and are more likely to suffer from sleep disturbances than those with episodic headache. Melatonin is a hormone secreted from the pineal gland. Melatonin is an antioxidant, antinociceptive, hypnotic, anticonvulsant, neuroprotective, anxiolytic, sedative and analgesic. This observational study aims to investigate clinical characteristics of patients with MOH and to explore the relationship between the serum melatonin level and medication overuse headache. Researchers hope to provide a new idea for the clinical treatment of MOH: melatonin can be used as an adjuvant therapy for MOH in the future.
Detailed description
30 patients with MOH，30 patients with episodic migraine and 30 age-matched healthy volunteers were recruited in the study. A series of neuropsychological test scale including Hospital Anxiety and Depression Scale (HADS), Pittsburgh sleep quality index (PSQI) and Leeds Dependence Questionnaire (LDQ) were evaluated among all the recruited. Blood samples were taken at 10 a.m. and centrifuged. The serum was separated and collected at -70 °C for the measurement of melatonin .
Interventions
None listed
Sponsors
The First Affiliated Hospital with Nanjing Medical University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Subject has medication overuse headache. Headache occurring on 15 or more days per month for more than 3 months. The number of medication days ≥10 days/month for triptans, ergotamine, opioids, combination analgesics, or multiple drug classes not individually overused; ≥15 days/ month for simple analgesic * Subject has had 1-8 migraines per month over the previous 3 months * Sign the informed consent
Exclusion criteria
* Subjects combine with other pain syndromes and long-term oral analgesics are needed * History of bleeding disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum melatonin level | 30 minutes | Blood samples taken for melatonin were centrifuged, and the serum content was separated and collected for analysis at -70 °C. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hospital Anxiety and Depression Scale (HADS) | 15 minutes | The subscore of HADS \>7 is considered as possible anxiety or depression. |
| Pittsburgh sleep quality index (PSQI) | 15 minutes | An overall score over 5 indicates poor sleep. |
| Leeds Dependence Questionnaire (LDQ) | 15 minutes | The LDQ is a 10-item, self completion questionnaire designed to measure dependence upon a variety of substances. |
Countries
China
Contacts
Primary ContactQi Wan, professor
Backup ContactHuimin Tao, master
Outcome results
None listed