Sports Nutritional Physiological Phenomena
Conditions
Keywords
Physiological Phenomena
Brief summary
Although β-alanine (BA) has been shown to be an effective ergogenic aid, little information exists on the safety of chronic supplementation despite potential concerns. The aim of this study was to investigate the effects of chronic BA supplementation on muscle taurine content, blood clinical markers and sensory side-effects during 24 weeks of BA supplementation.
Interventions
DIETARY_SUPPLEMENTBeta-alanine
Beta-alanine in sustained-release tablets to increase muscle carnosine content
DIETARY_SUPPLEMENTPlacebo
Maltodextrin is used as a placebo as it does not lead to any increases in muscle carnosine
Sponsors
University of Sao Paulo
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy males
Exclusion criteria
* Smokers * Chronic disease * Prior or current use of steroids * Use of creatine in the last 6 months * Use of beta-alanine in the last 6 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle taurine content in mmol/kg | Up to 24 weeks | Change in the content of taurine in muscle will be determined using High-Pressure Liquid Chromatography of muscle biopsies |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Aspartate transaminase; alanine aminotransferase; alkaline phosphatase; lactate dehydrogenase and creatine kinase in U/L | Up to 24 weeks | Aspartate transaminase; alanine aminotransferase; alkaline phosphatase; lactate dehydrogenase and creatine kinase will be analysed from venous blood samples |
| Albumin; globulin; creatinine in mg/dL | Up to 24 weeks | Albumin; globulin; creatinine will be analysed from venous blood samples |
Outcome results
None listed