Influenza Vaccine Allergy, Influenza Virus Vaccine Adverse Reaction
Conditions
Keywords
Influenza vaccination, elite athletes, Immune response, Side effects
Brief summary
Seasonal influenza vaccination was used to assess whether induction of immunity as well as the rate of side effects is influenced by the timing of the last training session before vaccination. Healthy athletes were vaccinated with the tetravalent influenza vaccine and blood samples were collected before, 1, 2 and 26 weeks after vaccination. The athletes were randomly assigned to vaccination within 2 hours after the last training session (2h) vs. vaccination after a resting period of at least 26 hours (26h). All participants documented side effects and training restrictions. Influenza-specific T-cells were quantified after stimulation with the vaccine based on intracellular cytokine staining. Antibodies were quantified by ELISA and neutralisation assay.
Interventions
BIOLOGICALInfluenza Vaccination
Influenza vaccination Influsplit Tetra 2016/2017, GlaxoSmithKline GmbH & Co. KG, Munich, Germany, batch: AFLBA 152AB.
Sponsors
Federal Institute of Sport Science
Universität des Saarlandes
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* performance-oriented training on at least five days a week, healthy athletes
Exclusion criteria
* current acute infection, allergy to the vaccine, immunosuppression, pregnancy, rheumatic diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Immune response | 26 weeks | Influenza-specific T-cells were quantified after stimulation with the vaccine based on intracellular cytokine staining. Antibodies were quantified by ELISA and neutralisation assay. |
| Rate of side effects | 2 weeks | All participants documented side effects and training restrictions. |
Outcome results
None listed