Mortality, Sepsis, Sleep Apnea Syndromes
Conditions
Keywords
obstructive sleep apnea, sepsis, outcome, prognosis, sleep-disordered breathing
Brief summary
By clinical record review, this retrospective study aims to compare the mortality of sepsis patients with versus without obstructive sleep apnea, who were diagnosed and treated in Taipei Veterans General Hospital, Taiwan.
Detailed description
This retrospective study aims to compare the mortality of sepsis patients with versus without obstructive sleep apnea (OSA). Patients with a diagnosis of sepsis, who had received a prior polysomnography at Taipei Veterans General Hospital during Jan. 1, 2001 to May 31, 2017 will be enrolled. Obstructive sleep apnea (OSA) is defined by an apnea-hypopnea index at least 5/hr with compatible symptoms. Their clinical record will be reviewed and data including demography, polysomnography and details related to sepsis (source of infection, number of organ dysfunction at initial diagnosis of sepsis and survival time) will be collected. The start of the survival time (follow-up time) is the date when sepsis is diagnosed. The end of the survival time (follow-up time) is the date of death or end of hospitalization (date of discharge). Survival analyses will be performed.
Interventions
BIOLOGICALOSA
The diagnosis of OSA (obstructive sleep apnea) relies on polysomnographic data showing an apnea-hypopnea index at least 5/hr with compatible symptoms.
Sponsors
Taipei Veterans General Hospital, Taiwan
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients who received received a polysomnography at Taipei Veterans General Hospital during Jan. 1, 2001 to May 31, 2017 2. Patients who were admitted with a diagnosis of sepsis after the polysomnography 3. The diagnosis of sepsis fulfilling the clinical criteria
Exclusion criteria
1. Younger than 20 years 2. Not compatible with a definition of sepsis 3. subjects with incomplete data
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mortality | up to 40 days | percentage of sepsis patients died of sepsis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Survival time | up to 40 days | Survival time is defined as the length from the date when sepsis is diagnosed to date of discharge or death |
| Mortality | 7-day | percentage of sepsis patients died of sepsis |
Countries
Taiwan
Contacts
Primary ContactKun-Ta Chou, M.D
Outcome results
None listed