Phrenic Nerve Paralysis
Conditions
Keywords
non-intubated general anaesthesia, video-assisted thoracoscopic surgery, phrenic block
Brief summary
Putting 80 patients divided into group S（non-intubated general anesthesia combine with Paravertebral blocks、surface spray anesthesia and Vagus block） and group D（non-intubated general anesthesia combine with Paravertebral blocks、surface spray anesthesia、Vagus block and Phrenic block）randomly,compare the volume of anesthetic and the number of increasing anesthetic during operation were compared between the two groups.If the date of group S greater than group D，it shows that the effect of anesthetic effect of group D is better than group S.
Detailed description
1. Put 80 patients divided into group S（non-intubated general anesthesia combine with Paravertebral blocks、surface spray anesthesia and Vagus block） and group D（non-intubated general anesthesia combine with Paravertebral blocks、surface spray anesthesia、Vagus block and Phrenic block）randomly. 2. Compare the volume of anesthetic drugs between the two groups. 3. If the date of group S greater than group D，it shows that the effect of anesthetic effect of group D is better than group S.
Interventions
PROCEDUREphrenic block
phrenic block by 1% ropivacaine 5ml
PROCEDUREno phrenic block
no phrenic block
Sponsors
Shenzhen People's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
Volunteers and data collectors was masked
Intervention model description
1. Put 80 patients divided into group S（non-intubated general anesthesia combine with Paravertebral blocks、surface spray anesthesia and Vagus block） and group D（non-intubated general anesthesia combine with Paravertebral blocks、surface spray anesthesia、Vagus block and Phrenic block）randomly. 2. Compare the volume of anesthetic drugs between the two groups. 3. If the date of group S greater than group D，it shows that the effect of anesthetic effect of group D is better than group S.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* The patient agreed to perform non-intubated video-assisted thoracoscopic surgery, and informed the possibility of intraoperative tracheal intubation or thoracotomy. * No conventional anesthesia contraindication, no history of thoracic surgery, good cardiopulmonary function. * There is no severe adhesion and calcification in the thoracic cavity, and no artificial pneumothorax is affected. * the patient has no serious anxiety or depression. * Small surgical trauma, simple steps, short time.
Exclusion criteria
* Mallampati≥3. * BMI≥26 kg/m2. * Hemodynamic instability. * INR≥1.5. * Respiratory infection, persistent cough or airway mucus hypersecretion, high risk of reflux. * nervous system disease,such as seizure or brain edema. * Extensive pleural adhesions or once chest surgery. * PaO2\<60mmHg or PaCO2\>50 mmHg. * Central hypopnea syndrome. * Lung isolation should be used to protect the healthy side of the lung. * Complicated operation, large trauma, long time, lack of experience or poor cooperation in the surgical team. * Contraindications to local anesthetic.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the volume of anesthetic drugs | the time of operation， an average of 4 hours | the volume of anesthetic drugs including sevoflurane,propofol and opioids during the operation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the time to get out of bed after surgery | two days after surgery | note the time to get out of bed after surgery |
| the cost of hospitalization | the time of hospitalization， an average of 7 days | note the the cost of hospitalization |
Countries
China
Outcome results
None listed